Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma

A subset of clear cell renal cell carcinoma (ccRCC) tumors exhibit a HIF1A gene mutation, yielding two ccRCC tumor types, H1H2 type expressing both HIF1α and HIF2α, and H2 type expressing HIF2α, but not functional HIF1α protein. However, it is unclear how the H1H2 type ccRCC tumors escape HIF1'...

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Detalles Bibliográficos
Autores principales: Murakami, A, Wang, L, Kalhorn, S, Schraml, P, Rathmell, W K, Tan, A C, Nemenoff, R, Stenmark, K, Jiang, B-H, Reyland, M E, Heasley, L, Hu, C-J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294252/
https://www.ncbi.nlm.nih.gov/pubmed/28092369
http://dx.doi.org/10.1038/oncsis.2016.89

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294252/
https://www.ncbi.nlm.nih.gov/pubmed/28092369
http://dx.doi.org/10.1038/oncsis.2016.89

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