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Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI
Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natur...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294399/ https://www.ncbi.nlm.nih.gov/pubmed/28169369 http://dx.doi.org/10.1038/srep42093 |
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author | Schuenke, Patrick Paech, Daniel Koehler, Christina Windschuh, Johannes Bachert, Peter Ladd, Mark E. Schlemmer, Heinz-Peter Radbruch, Alexander Zaiss, Moritz |
author_facet | Schuenke, Patrick Paech, Daniel Koehler, Christina Windschuh, Johannes Bachert, Peter Ladd, Mark E. Schlemmer, Heinz-Peter Radbruch, Alexander Zaiss, Moritz |
author_sort | Schuenke, Patrick |
collection | PubMed |
description | Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natural unlabeled D-glucose can be used as a nontoxic biodegradable contrast agent in Chemical Exchange sensitive Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect the glucose uptake and potentially the metabolism of tumors. As an important step to fulfill the clinical needs for practicability, reproducibility and imaging speed we present here a robust and quantitative T(1ρ)-weighted technique for dynamic glucose enhanced MRI (DGE-MRI) with a temporal resolution of less than 7 seconds. Applied to a brain tumor patient, the new technique provided a distinct DGE contrast between tumor and healthy brain tissue and showed the detailed dynamics of the glucose enhancement after intravenous injection. Development of this fast and quantitative DGE-MRI technique allows for a more detailed analysis of DGE correlations in the future and potentially enables non-invasive diagnosis, staging and monitoring of tumor response to therapy. |
format | Online Article Text |
id | pubmed-5294399 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-52943992017-02-10 Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI Schuenke, Patrick Paech, Daniel Koehler, Christina Windschuh, Johannes Bachert, Peter Ladd, Mark E. Schlemmer, Heinz-Peter Radbruch, Alexander Zaiss, Moritz Sci Rep Article Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natural unlabeled D-glucose can be used as a nontoxic biodegradable contrast agent in Chemical Exchange sensitive Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect the glucose uptake and potentially the metabolism of tumors. As an important step to fulfill the clinical needs for practicability, reproducibility and imaging speed we present here a robust and quantitative T(1ρ)-weighted technique for dynamic glucose enhanced MRI (DGE-MRI) with a temporal resolution of less than 7 seconds. Applied to a brain tumor patient, the new technique provided a distinct DGE contrast between tumor and healthy brain tissue and showed the detailed dynamics of the glucose enhancement after intravenous injection. Development of this fast and quantitative DGE-MRI technique allows for a more detailed analysis of DGE correlations in the future and potentially enables non-invasive diagnosis, staging and monitoring of tumor response to therapy. Nature Publishing Group 2017-02-07 /pmc/articles/PMC5294399/ /pubmed/28169369 http://dx.doi.org/10.1038/srep42093 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Schuenke, Patrick Paech, Daniel Koehler, Christina Windschuh, Johannes Bachert, Peter Ladd, Mark E. Schlemmer, Heinz-Peter Radbruch, Alexander Zaiss, Moritz Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title | Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title_full | Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title_fullStr | Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title_full_unstemmed | Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title_short | Fast and Quantitative T1ρ-weighted Dynamic Glucose Enhanced MRI |
title_sort | fast and quantitative t1ρ-weighted dynamic glucose enhanced mri |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294399/ https://www.ncbi.nlm.nih.gov/pubmed/28169369 http://dx.doi.org/10.1038/srep42093 |
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