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The value of delta neutrophil index in young infants with febrile urinary tract infection

Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral...

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Autores principales: Lee, Jung Won, Kim, Seong Heon, Park, Se Jin, Lee, Keum Hwa, Park, Jae Hyon, Kronbichler, Andreas, Eisenhut, Michael, Kim, Ji Hong, Lee, Jong Wook, Shin, Jae Il
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294644/
https://www.ncbi.nlm.nih.gov/pubmed/28169298
http://dx.doi.org/10.1038/srep41265
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author Lee, Jung Won
Kim, Seong Heon
Park, Se Jin
Lee, Keum Hwa
Park, Jae Hyon
Kronbichler, Andreas
Eisenhut, Michael
Kim, Ji Hong
Lee, Jong Wook
Shin, Jae Il
author_facet Lee, Jung Won
Kim, Seong Heon
Park, Se Jin
Lee, Keum Hwa
Park, Jae Hyon
Kronbichler, Andreas
Eisenhut, Michael
Kim, Ji Hong
Lee, Jong Wook
Shin, Jae Il
author_sort Lee, Jung Won
collection PubMed
description Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95% CI 0.558–0.687, P < 0.01) as well as for CRP (0.731, 95% CI 0.673–0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95% CI 0.542–0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers.
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spelling pubmed-52946442017-02-10 The value of delta neutrophil index in young infants with febrile urinary tract infection Lee, Jung Won Kim, Seong Heon Park, Se Jin Lee, Keum Hwa Park, Jae Hyon Kronbichler, Andreas Eisenhut, Michael Kim, Ji Hong Lee, Jong Wook Shin, Jae Il Sci Rep Article Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95% CI 0.558–0.687, P < 0.01) as well as for CRP (0.731, 95% CI 0.673–0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95% CI 0.542–0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers. Nature Publishing Group 2017-02-07 /pmc/articles/PMC5294644/ /pubmed/28169298 http://dx.doi.org/10.1038/srep41265 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Lee, Jung Won
Kim, Seong Heon
Park, Se Jin
Lee, Keum Hwa
Park, Jae Hyon
Kronbichler, Andreas
Eisenhut, Michael
Kim, Ji Hong
Lee, Jong Wook
Shin, Jae Il
The value of delta neutrophil index in young infants with febrile urinary tract infection
title The value of delta neutrophil index in young infants with febrile urinary tract infection
title_full The value of delta neutrophil index in young infants with febrile urinary tract infection
title_fullStr The value of delta neutrophil index in young infants with febrile urinary tract infection
title_full_unstemmed The value of delta neutrophil index in young infants with febrile urinary tract infection
title_short The value of delta neutrophil index in young infants with febrile urinary tract infection
title_sort value of delta neutrophil index in young infants with febrile urinary tract infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294644/
https://www.ncbi.nlm.nih.gov/pubmed/28169298
http://dx.doi.org/10.1038/srep41265
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