Downregulation of miR-130b~301b cluster is mediated by aberrant promoter methylation and impairs cellular senescence in prostate cancer

BACKGROUND: Numerous DNA-damaging cellular stresses, including oncogene activation and DNA-damage response (DDR), may lead to cellular senescence. Previous observations linked microRNA deregulation with altered senescent patterns, prompting us to investigate whether epigenetic repression of microRNA...

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Detalles Bibliográficos
Autores principales: Ramalho-Carvalho, João, Graça, Inês, Gomez, Antonio, Oliveira, Jorge, Henrique, Rui, Esteller, Manel, Jerónimo, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294724/
https://www.ncbi.nlm.nih.gov/pubmed/28166834
http://dx.doi.org/10.1186/s13045-017-0415-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294724/
https://www.ncbi.nlm.nih.gov/pubmed/28166834
http://dx.doi.org/10.1186/s13045-017-0415-1

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