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Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis

OBJECTIVE: To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS: Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimoda...

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Autores principales: de Albuquerque, Milena, Branco, Lucas Melo T, Rezende, Thiago Junqueira R., de Andrade, Helen Maia Tavares, Nucci, Anamarli, França Jr, Marcondes Cavalcante
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294732/
https://www.ncbi.nlm.nih.gov/pubmed/28203530
http://dx.doi.org/10.1016/j.nicl.2017.01.024
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author de Albuquerque, Milena
Branco, Lucas Melo T
Rezende, Thiago Junqueira R.
de Andrade, Helen Maia Tavares
Nucci, Anamarli
França Jr, Marcondes Cavalcante
author_facet de Albuquerque, Milena
Branco, Lucas Melo T
Rezende, Thiago Junqueira R.
de Andrade, Helen Maia Tavares
Nucci, Anamarli
França Jr, Marcondes Cavalcante
author_sort de Albuquerque, Milena
collection PubMed
description OBJECTIVE: To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS: Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimodal analyses of MRI included cortical thickness measurements (FreeSurfer software), analysis of white matter integrity using diffusion-tensor imaging (tract-based spatial statistics-TBSS) and measurement of cervical spinal cord cross-sectional area (SpineSeg software). All analyses were corrected for multiple comparisons. The standardized response mean (SRM = mean score change / standard deviation of score change) was calculated for all methods herein employed and used for comparison purposes. RESULTS: There were 18 men and mean age at first examination was 51.9 years. Mean ALSFRS-R scores at baseline and follow-up were 34.0 and 29.0, respectively. There was no region with progressive cortical thinning, but there was significant brainstem volumetric reduction (p = 0.001). TBSS analyses revealed progressive increase of AD (axial diffusivity) and MD (mean diffusivity) at the corpus callosum (p < 0.05), whereas SpineSeg showed progressive cord area reduction (p = 0.002). Cervical spinal cord cross-sectional area reduction was the only MRI parameter that correlated with ALSFRS-R change (r = 0.309, p = 0.038). SRM for ALSFRS-R was 0.95, for cord area 0.95, for corpus callosum AD 0.62 and MD 0.65, and for brainstem volume 0.002. CONCLUSIONS: Structural MRI is able to detect short term longitudinal changes in ALS. Cervical spinal cord morphometry is a promising neuroimaging marker to assess ALS course.
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spelling pubmed-52947322017-02-15 Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis de Albuquerque, Milena Branco, Lucas Melo T Rezende, Thiago Junqueira R. de Andrade, Helen Maia Tavares Nucci, Anamarli França Jr, Marcondes Cavalcante Neuroimage Clin Regular Article OBJECTIVE: To evaluate MRI-based parameters as biomarkers of Amyotrophic Lateral Sclerosis (ALS) progression. METHODS: Twenty-seven patients and 27 controls performed two clinical and MRI acquisitions 8 months apart. ALSFRS-R scale was used to quantify disease severity at both time points. Multimodal analyses of MRI included cortical thickness measurements (FreeSurfer software), analysis of white matter integrity using diffusion-tensor imaging (tract-based spatial statistics-TBSS) and measurement of cervical spinal cord cross-sectional area (SpineSeg software). All analyses were corrected for multiple comparisons. The standardized response mean (SRM = mean score change / standard deviation of score change) was calculated for all methods herein employed and used for comparison purposes. RESULTS: There were 18 men and mean age at first examination was 51.9 years. Mean ALSFRS-R scores at baseline and follow-up were 34.0 and 29.0, respectively. There was no region with progressive cortical thinning, but there was significant brainstem volumetric reduction (p = 0.001). TBSS analyses revealed progressive increase of AD (axial diffusivity) and MD (mean diffusivity) at the corpus callosum (p < 0.05), whereas SpineSeg showed progressive cord area reduction (p = 0.002). Cervical spinal cord cross-sectional area reduction was the only MRI parameter that correlated with ALSFRS-R change (r = 0.309, p = 0.038). SRM for ALSFRS-R was 0.95, for cord area 0.95, for corpus callosum AD 0.62 and MD 0.65, and for brainstem volume 0.002. CONCLUSIONS: Structural MRI is able to detect short term longitudinal changes in ALS. Cervical spinal cord morphometry is a promising neuroimaging marker to assess ALS course. Elsevier 2017-01-24 /pmc/articles/PMC5294732/ /pubmed/28203530 http://dx.doi.org/10.1016/j.nicl.2017.01.024 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
de Albuquerque, Milena
Branco, Lucas Melo T
Rezende, Thiago Junqueira R.
de Andrade, Helen Maia Tavares
Nucci, Anamarli
França Jr, Marcondes Cavalcante
Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title_full Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title_fullStr Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title_full_unstemmed Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title_short Longitudinal evaluation of cerebral and spinal cord damage in Amyotrophic Lateral Sclerosis
title_sort longitudinal evaluation of cerebral and spinal cord damage in amyotrophic lateral sclerosis
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294732/
https://www.ncbi.nlm.nih.gov/pubmed/28203530
http://dx.doi.org/10.1016/j.nicl.2017.01.024
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