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Heat stress induces ferroptosis-like cell death in plants

In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process c...

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Autores principales: Distéfano, Ayelén Mariana, Martin, María Victoria, Córdoba, Juan Pablo, Bellido, Andrés Martín, D’Ippólito, Sebastián, Colman, Silvana Lorena, Soto, Débora, Roldán, Juan Alfredo, Bartoli, Carlos Guillermo, Zabaleta, Eduardo Julián, Fiol, Diego Fernando, Stockwell, Brent R., Dixon, Scott J., Pagnussat, Gabriela Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294777/
https://www.ncbi.nlm.nih.gov/pubmed/28100685
http://dx.doi.org/10.1083/jcb.201605110
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author Distéfano, Ayelén Mariana
Martin, María Victoria
Córdoba, Juan Pablo
Bellido, Andrés Martín
D’Ippólito, Sebastián
Colman, Silvana Lorena
Soto, Débora
Roldán, Juan Alfredo
Bartoli, Carlos Guillermo
Zabaleta, Eduardo Julián
Fiol, Diego Fernando
Stockwell, Brent R.
Dixon, Scott J.
Pagnussat, Gabriela Carolina
author_facet Distéfano, Ayelén Mariana
Martin, María Victoria
Córdoba, Juan Pablo
Bellido, Andrés Martín
D’Ippólito, Sebastián
Colman, Silvana Lorena
Soto, Débora
Roldán, Juan Alfredo
Bartoli, Carlos Guillermo
Zabaleta, Eduardo Julián
Fiol, Diego Fernando
Stockwell, Brent R.
Dixon, Scott J.
Pagnussat, Gabriela Carolina
author_sort Distéfano, Ayelén Mariana
collection PubMed
description In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient.
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spelling pubmed-52947772017-08-01 Heat stress induces ferroptosis-like cell death in plants Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina J Cell Biol Research Articles In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient. The Rockefeller University Press 2017-02 /pmc/articles/PMC5294777/ /pubmed/28100685 http://dx.doi.org/10.1083/jcb.201605110 Text en © 2017 Distéfano et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Research Articles
Distéfano, Ayelén Mariana
Martin, María Victoria
Córdoba, Juan Pablo
Bellido, Andrés Martín
D’Ippólito, Sebastián
Colman, Silvana Lorena
Soto, Débora
Roldán, Juan Alfredo
Bartoli, Carlos Guillermo
Zabaleta, Eduardo Julián
Fiol, Diego Fernando
Stockwell, Brent R.
Dixon, Scott J.
Pagnussat, Gabriela Carolina
Heat stress induces ferroptosis-like cell death in plants
title Heat stress induces ferroptosis-like cell death in plants
title_full Heat stress induces ferroptosis-like cell death in plants
title_fullStr Heat stress induces ferroptosis-like cell death in plants
title_full_unstemmed Heat stress induces ferroptosis-like cell death in plants
title_short Heat stress induces ferroptosis-like cell death in plants
title_sort heat stress induces ferroptosis-like cell death in plants
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294777/
https://www.ncbi.nlm.nih.gov/pubmed/28100685
http://dx.doi.org/10.1083/jcb.201605110
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