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Heat stress induces ferroptosis-like cell death in plants
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process c...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294777/ https://www.ncbi.nlm.nih.gov/pubmed/28100685 http://dx.doi.org/10.1083/jcb.201605110 |
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author | Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina |
author_facet | Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina |
author_sort | Distéfano, Ayelén Mariana |
collection | PubMed |
description | In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient. |
format | Online Article Text |
id | pubmed-5294777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-52947772017-08-01 Heat stress induces ferroptosis-like cell death in plants Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina J Cell Biol Research Articles In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses. Ferroptosis is an iron-dependent, oxidative, nonapoptotic form of cell death recently described in animal cells. In animal cells, this process can be triggered by depletion of glutathione (GSH) and accumulation of lipid reactive oxygen species (ROS). We investigated whether a similar process could be relevant to cell death in plants. Remarkably, heat shock (HS)–induced RCD, but not reproductive or vascular development, was found to involve a ferroptosis-like cell death process. In root cells, HS triggered an iron-dependent cell death pathway that was characterized by depletion of GSH and ascorbic acid and accumulation of cytosolic and lipid ROS. These results suggest a physiological role for this lethal pathway in response to heat stress in Arabidopsis thaliana. The similarity of ferroptosis in animal cells and ferroptosis-like death in plants suggests that oxidative, iron-dependent cell death programs may be evolutionarily ancient. The Rockefeller University Press 2017-02 /pmc/articles/PMC5294777/ /pubmed/28100685 http://dx.doi.org/10.1083/jcb.201605110 Text en © 2017 Distéfano et al. http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Research Articles Distéfano, Ayelén Mariana Martin, María Victoria Córdoba, Juan Pablo Bellido, Andrés Martín D’Ippólito, Sebastián Colman, Silvana Lorena Soto, Débora Roldán, Juan Alfredo Bartoli, Carlos Guillermo Zabaleta, Eduardo Julián Fiol, Diego Fernando Stockwell, Brent R. Dixon, Scott J. Pagnussat, Gabriela Carolina Heat stress induces ferroptosis-like cell death in plants |
title | Heat stress induces ferroptosis-like cell death in plants |
title_full | Heat stress induces ferroptosis-like cell death in plants |
title_fullStr | Heat stress induces ferroptosis-like cell death in plants |
title_full_unstemmed | Heat stress induces ferroptosis-like cell death in plants |
title_short | Heat stress induces ferroptosis-like cell death in plants |
title_sort | heat stress induces ferroptosis-like cell death in plants |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294777/ https://www.ncbi.nlm.nih.gov/pubmed/28100685 http://dx.doi.org/10.1083/jcb.201605110 |
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