Shutting down the power supply for DNA repair in cancer cells

Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination–mediated DNA repair, suggesting that targeting m...

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Detalles Bibliográficos
Autor principal: van Vugt, Marcel A.T.M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294795/
https://www.ncbi.nlm.nih.gov/pubmed/28122958
http://dx.doi.org/10.1083/jcb.201701026
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author van Vugt, Marcel A.T.M.
author_facet van Vugt, Marcel A.T.M.
author_sort van Vugt, Marcel A.T.M.
collection PubMed
description Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination–mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents.
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spelling pubmed-52947952017-08-01 Shutting down the power supply for DNA repair in cancer cells van Vugt, Marcel A.T.M. J Cell Biol Commentary Phosphoglycerate mutase 1 (PGAM1) functions in glycolysis. In this issue, Qu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201607008) show that PGAM1 inactivation leads to nucleotide depletion, which causes defective homologous recombination–mediated DNA repair, suggesting that targeting metabolic enzymes increases cancer cell susceptibility to DNA damaging agents. The Rockefeller University Press 2017-02 /pmc/articles/PMC5294795/ /pubmed/28122958 http://dx.doi.org/10.1083/jcb.201701026 Text en © 2017 van Vugt http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentary
van Vugt, Marcel A.T.M.
Shutting down the power supply for DNA repair in cancer cells
title Shutting down the power supply for DNA repair in cancer cells
title_full Shutting down the power supply for DNA repair in cancer cells
title_fullStr Shutting down the power supply for DNA repair in cancer cells
title_full_unstemmed Shutting down the power supply for DNA repair in cancer cells
title_short Shutting down the power supply for DNA repair in cancer cells
title_sort shutting down the power supply for dna repair in cancer cells
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294795/
https://www.ncbi.nlm.nih.gov/pubmed/28122958
http://dx.doi.org/10.1083/jcb.201701026
work_keys_str_mv AT vanvugtmarcelatm shuttingdownthepowersupplyfordnarepairincancercells

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