Cargando…
The epidermal polarity protein Par3 is a non–cell autonomous suppressor of malignant melanoma
Melanoma, an aggressive skin malignancy with increasing lifetime risk, originates from melanocytes (MCs) that are in close contact with surrounding epidermal keratinocytes (KCs). How the epidermal microenvironment controls melanomagenesis remains poorly understood. In this study, we identify an unex...
Autores principales: | Mescher, Melina, Jeong, Peter, Knapp, Sina K., Rübsam, Matthias, Saynisch, Michael, Kranen, Marina, Landsberg, Jennifer, Schlaak, Max, Mauch, Cornelia, Tüting, Thomas, Niessen, Carien M., Iden, Sandra |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294851/ https://www.ncbi.nlm.nih.gov/pubmed/28096290 http://dx.doi.org/10.1084/jem.20160596 |
Ejemplares similares
-
Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis
por: Vorhagen, Susanne, et al.
Publicado: (2018) -
Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity
por: Dias Gomes, Martim, et al.
Publicado: (2019) -
The Desmosome-Keratin Scaffold Integrates ErbB Family and Mechanical Signaling to Polarize Epidermal Structure and Function
por: Green, Kathleen J., et al.
Publicado: (2022) -
Polarity signaling balances epithelial contractility and mechanical resistance
por: Rübsam, Matthias, et al.
Publicado: (2023) -
Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth
por: Pach, Elke, et al.
Publicado: (2021)