Defective ATG16L1-mediated removal of IRE1α drives Crohn’s disease–like ileitis

ATG16L1(T300A), a major risk polymorphism in Crohn’s disease (CD), causes impaired autophagy, but it has remained unclear how this predisposes to CD. In this study, we report that mice with Atg16l1 deletion in intestinal epithelial cells (IECs) spontaneously develop transmural ileitis phenocopying i...

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Detalles Bibliográficos
Autores principales: Tschurtschenthaler, Markus, Adolph, Timon E., Ashcroft, Jonathan W., Niederreiter, Lukas, Bharti, Richa, Saveljeva, Svetlana, Bhattacharyya, Joya, Flak, Magdalena B., Shih, David Q., Fuhler, Gwenny M., Parkes, Miles, Kohno, Kenji, Iwawaki, Takao, Janneke van der Woude, C., Harding, Heather P., Smith, Andrew M., Peppelenbosch, Maikel P., Targan, Stephan R., Ron, David, Rosenstiel, Philip, Blumberg, Richard S., Kaser, Arthur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294857/
https://www.ncbi.nlm.nih.gov/pubmed/28082357
http://dx.doi.org/10.1084/jem.20160791

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