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Antibody-secreting plasma cells persist for decades in human intestine
Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294861/ https://www.ncbi.nlm.nih.gov/pubmed/28104812 http://dx.doi.org/10.1084/jem.20161590 |
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| author | Landsverk, Ole J.B. Snir, Omri Casado, Raquel Bartolomé Richter, Lisa Mold, Jeff E. Réu, Pedro Horneland, Rune Paulsen, Vemund Yaqub, Sheraz Aandahl, Einar Martin Øyen, Ole M. Thorarensen, Hildur Sif Salehpour, Mehran Possnert, Göran Frisén, Jonas Sollid, Ludvig M. Baekkevold, Espen S. Jahnsen, Frode L. |
| author_facet | Landsverk, Ole J.B. Snir, Omri Casado, Raquel Bartolomé Richter, Lisa Mold, Jeff E. Réu, Pedro Horneland, Rune Paulsen, Vemund Yaqub, Sheraz Aandahl, Einar Martin Øyen, Ole M. Thorarensen, Hildur Sif Salehpour, Mehran Possnert, Göran Frisén, Jonas Sollid, Ludvig M. Baekkevold, Espen S. Jahnsen, Frode L. |
| author_sort | Landsverk, Ole J.B. |
| collection | PubMed |
| description | Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(−) PC subsets, CD45(+) PCs exhibited little and CD45(−) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(−) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(−) PC subsets support selection and maintenance of protective PCs for life in human intestine. |
| format | Online Article Text |
| id | pubmed-5294861 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | The Rockefeller University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-52948612017-08-01 Antibody-secreting plasma cells persist for decades in human intestine Landsverk, Ole J.B. Snir, Omri Casado, Raquel Bartolomé Richter, Lisa Mold, Jeff E. Réu, Pedro Horneland, Rune Paulsen, Vemund Yaqub, Sheraz Aandahl, Einar Martin Øyen, Ole M. Thorarensen, Hildur Sif Salehpour, Mehran Possnert, Göran Frisén, Jonas Sollid, Ludvig M. Baekkevold, Espen S. Jahnsen, Frode L. J Exp Med Research Articles Plasma cells (PCs) produce antibodies that mediate immunity after infection or vaccination. In contrast to PCs in the bone marrow, PCs in the gut have been considered short lived. In this study, we studied PC dynamics in the human small intestine by cell-turnover analysis in organ transplants and by retrospective cell birth dating measuring carbon-14 in genomic DNA. We identified three distinct PC subsets: a CD19(+) PC subset was dynamically exchanged, whereas of two CD19(−) PC subsets, CD45(+) PCs exhibited little and CD45(−) PCs no replacement and had a median age of 11 and 22 yr, respectively. Accumulation of CD45(−) PCs during ageing and the presence of rotavirus-specific clones entirely within the CD19(−) PC subsets support selection and maintenance of protective PCs for life in human intestine. The Rockefeller University Press 2017-02 /pmc/articles/PMC5294861/ /pubmed/28104812 http://dx.doi.org/10.1084/jem.20161590 Text en © 2017 Landsverk et al. https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
| spellingShingle | Research Articles Landsverk, Ole J.B. Snir, Omri Casado, Raquel Bartolomé Richter, Lisa Mold, Jeff E. Réu, Pedro Horneland, Rune Paulsen, Vemund Yaqub, Sheraz Aandahl, Einar Martin Øyen, Ole M. Thorarensen, Hildur Sif Salehpour, Mehran Possnert, Göran Frisén, Jonas Sollid, Ludvig M. Baekkevold, Espen S. Jahnsen, Frode L. Antibody-secreting plasma cells persist for decades in human intestine |
| title | Antibody-secreting plasma cells persist for decades in human intestine |
| title_full | Antibody-secreting plasma cells persist for decades in human intestine |
| title_fullStr | Antibody-secreting plasma cells persist for decades in human intestine |
| title_full_unstemmed | Antibody-secreting plasma cells persist for decades in human intestine |
| title_short | Antibody-secreting plasma cells persist for decades in human intestine |
| title_sort | antibody-secreting plasma cells persist for decades in human intestine |
| topic | Research Articles |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294861/ https://www.ncbi.nlm.nih.gov/pubmed/28104812 http://dx.doi.org/10.1084/jem.20161590 |
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