IKKα controls ATG16L1 degradation to prevent ER stress during inflammation

Inhibition of the IκB kinase complex (IKK) has been implicated in the therapy of several chronic inflammatory diseases including inflammatory bowel diseases. In this study, using mice with an inactivatable IKKα kinase (Ikkα(AA/AA)), we show that loss of IKKα function markedly impairs epithelial rege...

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Detalles Bibliográficos
Autores principales: Diamanti, Michaela A., Gupta, Jalaj, Bennecke, Moritz, De Oliveira, Tiago, Ramakrishnan, Mallika, Braczynski, Anne K., Richter, Benjamin, Beli, Petra, Hu, Yinling, Saleh, Maya, Mittelbronn, Michel, Dikic, Ivan, Greten, Florian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294863/
https://www.ncbi.nlm.nih.gov/pubmed/28082356
http://dx.doi.org/10.1084/jem.20161867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294863/
https://www.ncbi.nlm.nih.gov/pubmed/28082356
http://dx.doi.org/10.1084/jem.20161867

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