TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research

Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression...

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Detalles Bibliográficos
Autores principales: Yokobori, Takehiko, Nishiyama, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294964/
https://www.ncbi.nlm.nih.gov/pubmed/28106769
http://dx.doi.org/10.3390/jcm6010011
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author Yokobori, Takehiko
Nishiyama, Masahiko
author_facet Yokobori, Takehiko
Nishiyama, Masahiko
author_sort Yokobori, Takehiko
collection PubMed
description Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-β-induced protein (TGFBI)—a downstream component of the TGF-β signaling pathway—has been shown to promote and/or inhibit cancer. Here, we review the state of basic and clinical research on the roles of TGF-β and TGFBI in gastrointestinal cancers.
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spelling pubmed-52949642017-02-10 TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research Yokobori, Takehiko Nishiyama, Masahiko J Clin Med Review Transforming growth factor (TGF)-β superfamily proteins have many important biological functions, including regulation of tissue differentiation, cell proliferation, and migration in both normal and cancer cells. Many studies have reported that TGF-β signaling is associated with disease progression and therapeutic resistance in several cancers. Similarly, TGF-β-induced protein (TGFBI)—a downstream component of the TGF-β signaling pathway—has been shown to promote and/or inhibit cancer. Here, we review the state of basic and clinical research on the roles of TGF-β and TGFBI in gastrointestinal cancers. MDPI 2017-01-18 /pmc/articles/PMC5294964/ /pubmed/28106769 http://dx.doi.org/10.3390/jcm6010011 Text en © 2017 by the author; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yokobori, Takehiko
Nishiyama, Masahiko
TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title_full TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title_fullStr TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title_full_unstemmed TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title_short TGF-β Signaling in Gastrointestinal Cancers: Progress in Basic and Clinical Research
title_sort tgf-β signaling in gastrointestinal cancers: progress in basic and clinical research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294964/
https://www.ncbi.nlm.nih.gov/pubmed/28106769
http://dx.doi.org/10.3390/jcm6010011
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