Astrovirus Pathogenesis

Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, ther...

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Detalles Bibliográficos
Autores principales: Johnson, Cydney, Hargest, Virginia, Cortez, Valerie, Meliopoulos, Victoria A., Schultz-Cherry, Stacey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294991/
https://www.ncbi.nlm.nih.gov/pubmed/28117758
http://dx.doi.org/10.3390/v9010022
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author Johnson, Cydney
Hargest, Virginia
Cortez, Valerie
Meliopoulos, Victoria A.
Schultz-Cherry, Stacey
author_facet Johnson, Cydney
Hargest, Virginia
Cortez, Valerie
Meliopoulos, Victoria A.
Schultz-Cherry, Stacey
author_sort Johnson, Cydney
collection PubMed
description Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems.
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spelling pubmed-52949912017-02-10 Astrovirus Pathogenesis Johnson, Cydney Hargest, Virginia Cortez, Valerie Meliopoulos, Victoria A. Schultz-Cherry, Stacey Viruses Review Astroviruses are a major cause of diarrhea in the young, elderly, and the immunocompromised. Since the discovery of human astrovirus type 1 (HAstV-1) in 1975, the family Astroviridae has expanded to include two more human clades and numerous mammalian and avian-specific genotypes. Despite this, there is still little known about pathogenesis. The following review highlights the current knowledge of astrovirus pathogenesis, and outlines the critical steps needed to further astrovirus research, including the development of animal models of cell culture systems. MDPI 2017-01-22 /pmc/articles/PMC5294991/ /pubmed/28117758 http://dx.doi.org/10.3390/v9010022 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Johnson, Cydney
Hargest, Virginia
Cortez, Valerie
Meliopoulos, Victoria A.
Schultz-Cherry, Stacey
Astrovirus Pathogenesis
title Astrovirus Pathogenesis
title_full Astrovirus Pathogenesis
title_fullStr Astrovirus Pathogenesis
title_full_unstemmed Astrovirus Pathogenesis
title_short Astrovirus Pathogenesis
title_sort astrovirus pathogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294991/
https://www.ncbi.nlm.nih.gov/pubmed/28117758
http://dx.doi.org/10.3390/v9010022
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AT hargestvirginia astroviruspathogenesis
AT cortezvalerie astroviruspathogenesis
AT meliopoulosvictoriaa astroviruspathogenesis
AT schultzcherrystacey astroviruspathogenesis

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