Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability

Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle co...

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Detalles Bibliográficos
Autores principales: Pozo, Pedro N., Cook, Jeanette Gowen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294997/
https://www.ncbi.nlm.nih.gov/pubmed/28025526
http://dx.doi.org/10.3390/genes8010002
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author Pozo, Pedro N.
Cook, Jeanette Gowen
author_facet Pozo, Pedro N.
Cook, Jeanette Gowen
author_sort Pozo, Pedro N.
collection PubMed
description Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability. We review here recent advances in elucidating Cdt1 molecular functions in both origin licensing and kinetochore–microtubule attachment, and we describe the current understanding of human Cdt1 regulation.
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spelling pubmed-52949972017-02-10 Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability Pozo, Pedro N. Cook, Jeanette Gowen Genes (Basel) Review Successful cell proliferation requires efficient and precise genome duplication followed by accurate chromosome segregation. The Cdc10-dependent transcript 1 protein (Cdt1) is required for the first step in DNA replication, and in human cells Cdt1 is also required during mitosis. Tight cell cycle controls over Cdt1 abundance and activity are critical to normal development and genome stability. We review here recent advances in elucidating Cdt1 molecular functions in both origin licensing and kinetochore–microtubule attachment, and we describe the current understanding of human Cdt1 regulation. MDPI 2016-12-22 /pmc/articles/PMC5294997/ /pubmed/28025526 http://dx.doi.org/10.3390/genes8010002 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pozo, Pedro N.
Cook, Jeanette Gowen
Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title_full Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title_fullStr Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title_full_unstemmed Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title_short Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability
title_sort regulation and function of cdt1; a key factor in cell proliferation and genome stability
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294997/
https://www.ncbi.nlm.nih.gov/pubmed/28025526
http://dx.doi.org/10.3390/genes8010002
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