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Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men

African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve...

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Autores principales: Nelson, Shakira M., Batai, Ken, Ahaghotu, Chiledum, Agurs-Collins, Tanya, Kittles, Rick A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295056/
https://www.ncbi.nlm.nih.gov/pubmed/28036013
http://dx.doi.org/10.3390/nu9010012
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author Nelson, Shakira M.
Batai, Ken
Ahaghotu, Chiledum
Agurs-Collins, Tanya
Kittles, Rick A.
author_facet Nelson, Shakira M.
Batai, Ken
Ahaghotu, Chiledum
Agurs-Collins, Tanya
Kittles, Rick A.
author_sort Nelson, Shakira M.
collection PubMed
description African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified; 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire. Vitamin D receptor polymorphisms from three different loci were genotyped; rs731236, rs1544410, and rs11568820. Multivariate logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) comparing aggressive to non-aggressive prostate cancer. Vitamin D deficiency (<20 ng/mL) significantly increased risk of aggressive disease (OR: 3.1, 95% CI: 1.03–9.57, p-value = 0.04). Stratification by total calcium showed high calcium levels (≥800 mg/day) modified this association (OR: 7.3, 95% CI: 2.15–47.68, p-interaction = 0.03). Genetic variant rs11568820 appeared to increase the magnitude of association between deficient serum vitamin D and aggressive prostate cancer (OR: 3.64, 95% CI: 1.12–11.75, p-value = 0.05). These findings suggest that high incidence of aggressive prostate cancer risk in African American men may be due in-part to deficient levels of serum vitamin D. Other factors, including genetics, should be considered for future studies.
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spelling pubmed-52950562017-02-10 Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men Nelson, Shakira M. Batai, Ken Ahaghotu, Chiledum Agurs-Collins, Tanya Kittles, Rick A. Nutrients Article African American men have higher incidence rates of aggressive prostate cancer, where high levels of calcium and serum vitamin D deficient levels play a role in the racial differences in incidence. In this study, we examined associations of serum vitamin D with aggressive prostate cancer to improve our understanding of higher susceptibility of aggressive disease in this racial cohort. From Howard University Hospital, 155 African American men with clinically-identified prostate cancer were identified; 46 aggressive cases, and 58 non-aggressive cases. Serum vitamin D was assessed from fasting blood samples, and total calcium intake was assessed using the Block Food Frequency Questionnaire. Vitamin D receptor polymorphisms from three different loci were genotyped; rs731236, rs1544410, and rs11568820. Multivariate logistic regression models were used to determine odds ratios (OR) and 95% confidence intervals (CI) comparing aggressive to non-aggressive prostate cancer. Vitamin D deficiency (<20 ng/mL) significantly increased risk of aggressive disease (OR: 3.1, 95% CI: 1.03–9.57, p-value = 0.04). Stratification by total calcium showed high calcium levels (≥800 mg/day) modified this association (OR: 7.3, 95% CI: 2.15–47.68, p-interaction = 0.03). Genetic variant rs11568820 appeared to increase the magnitude of association between deficient serum vitamin D and aggressive prostate cancer (OR: 3.64, 95% CI: 1.12–11.75, p-value = 0.05). These findings suggest that high incidence of aggressive prostate cancer risk in African American men may be due in-part to deficient levels of serum vitamin D. Other factors, including genetics, should be considered for future studies. MDPI 2016-12-28 /pmc/articles/PMC5295056/ /pubmed/28036013 http://dx.doi.org/10.3390/nu9010012 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nelson, Shakira M.
Batai, Ken
Ahaghotu, Chiledum
Agurs-Collins, Tanya
Kittles, Rick A.
Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title_full Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title_fullStr Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title_full_unstemmed Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title_short Association between Serum 25-Hydroxy-Vitamin D and Aggressive Prostate Cancer in African American Men
title_sort association between serum 25-hydroxy-vitamin d and aggressive prostate cancer in african american men
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295056/
https://www.ncbi.nlm.nih.gov/pubmed/28036013
http://dx.doi.org/10.3390/nu9010012
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