Cargando…

Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial

The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommen...

Descripción completa

Detalles Bibliográficos
Autores principales: Pilz, Stefan, Hahn, Andreas, Schön, Christiane, Wilhelm, Manfred, Obeid, Rima
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295074/
https://www.ncbi.nlm.nih.gov/pubmed/28054964
http://dx.doi.org/10.3390/nu9010030
_version_ 1782505360093872128
author Pilz, Stefan
Hahn, Andreas
Schön, Christiane
Wilhelm, Manfred
Obeid, Rima
author_facet Pilz, Stefan
Hahn, Andreas
Schön, Christiane
Wilhelm, Manfred
Obeid, Rima
author_sort Pilz, Stefan
collection PubMed
description The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25(OH)D. 196 participants completed the trial. Increases in 25(OH)D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25(OH)D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient.
format Online
Article
Text
id pubmed-5295074
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-52950742017-02-10 Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial Pilz, Stefan Hahn, Andreas Schön, Christiane Wilhelm, Manfred Obeid, Rima Nutrients Article The German Nutrition Society raised in 2012 the recommended daily vitamin D intake from 200 to 800 international units (IU) to achieve 25-hydroxyvitamin D (25(OH)D) levels of at least 50 nmol/L, even when endogenous vitamin D synthesis is minimal such as in winter. We aimed to evaluate this recommendation in women of childbearing age. This is a single-center, randomized, open trial conducted from 8 January to 9 May 2016 in Esslingen, Germany. We randomized 201 apparently healthy women to receive for 8 weeks a daily multimicronutrient supplement containing either 200 IU (n = 100) or 800 IU vitamin D3 (n = 101). Primary outcome measure was serum 25(OH)D. 196 participants completed the trial. Increases in 25(OH)D (median with interquartile range) from baseline to study end were 13.2 (5.9 to 20.7) nmol/L in the 200 IU group, and 35.8 (18.2 to 52.8) nmol/L in the 800 IU group (p < 0.001 for the between group difference). At study end, levels of ≥50 nmol/L were present in 70.4% of the 200 IU group and in 99% of the 800 IU group. Participants on hormonal contraceptives had higher baseline levels and a stronger increase in 25(OH)D. In conclusion, daily supplementation of 800 IU vitamin D3 during wintertime in Germany is sufficient to achieve a 25(OH)D level of at least 50 nmol/L in almost all women of childbearing age, whereas 200 IU are insufficient. MDPI 2017-01-04 /pmc/articles/PMC5295074/ /pubmed/28054964 http://dx.doi.org/10.3390/nu9010030 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pilz, Stefan
Hahn, Andreas
Schön, Christiane
Wilhelm, Manfred
Obeid, Rima
Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title_full Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title_fullStr Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title_full_unstemmed Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title_short Effect of Two Different Multimicronutrient Supplements on Vitamin D Status in Women of Childbearing Age: A Randomized Trial
title_sort effect of two different multimicronutrient supplements on vitamin d status in women of childbearing age: a randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295074/
https://www.ncbi.nlm.nih.gov/pubmed/28054964
http://dx.doi.org/10.3390/nu9010030
work_keys_str_mv AT pilzstefan effectoftwodifferentmultimicronutrientsupplementsonvitamindstatusinwomenofchildbearingagearandomizedtrial
AT hahnandreas effectoftwodifferentmultimicronutrientsupplementsonvitamindstatusinwomenofchildbearingagearandomizedtrial
AT schonchristiane effectoftwodifferentmultimicronutrientsupplementsonvitamindstatusinwomenofchildbearingagearandomizedtrial
AT wilhelmmanfred effectoftwodifferentmultimicronutrientsupplementsonvitamindstatusinwomenofchildbearingagearandomizedtrial
AT obeidrima effectoftwodifferentmultimicronutrientsupplementsonvitamindstatusinwomenofchildbearingagearandomizedtrial