Cargando…

Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet

Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could s...

Descripción completa

Detalles Bibliográficos
Autores principales: Yoneda, Toshiki, Tomofuji, Takaaki, Kunitomo, Muneyoshi, Ekuni, Daisuke, Irie, Koichiro, Azuma, Tetsuji, Machida, Tatsuya, Miyai, Hisataka, Fujimori, Kouhei, Morita, Manabu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295108/
https://www.ncbi.nlm.nih.gov/pubmed/28098768
http://dx.doi.org/10.3390/nu9010064
_version_ 1782505367696048128
author Yoneda, Toshiki
Tomofuji, Takaaki
Kunitomo, Muneyoshi
Ekuni, Daisuke
Irie, Koichiro
Azuma, Tetsuji
Machida, Tatsuya
Miyai, Hisataka
Fujimori, Kouhei
Morita, Manabu
author_facet Yoneda, Toshiki
Tomofuji, Takaaki
Kunitomo, Muneyoshi
Ekuni, Daisuke
Irie, Koichiro
Azuma, Tetsuji
Machida, Tatsuya
Miyai, Hisataka
Fujimori, Kouhei
Morita, Manabu
author_sort Yoneda, Toshiki
collection PubMed
description Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Male Fischer 344 rats (n = 18) were divided into three groups of six rats each: a control group (fed a regular diet and drinking distilled water) and two experimental groups (fed a high-fat diet and drinking distilled water or hydrogen-rich water). The level of 8-hydroxydeoxyguanosine was determined to evaluate oxidative stress. The bone mineral density of the alveolar bone was analyzed by micro-computerized tomography. Obese rats, induced by a high-fat diet, showed a higher gingival level of 8-hydroxydeoxyguanosine and a lower level of alveolar bone density compared to the control group. Drinking hydrogen-rich water suppressed body weight gain, lowered gingival level of 8-hydroxydeoxyguanosine, and reduced alveolar bone resorption in rats on a high-fat diet. The results indicate that hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption by limiting obesity.
format Online
Article
Text
id pubmed-5295108
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-52951082017-02-10 Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet Yoneda, Toshiki Tomofuji, Takaaki Kunitomo, Muneyoshi Ekuni, Daisuke Irie, Koichiro Azuma, Tetsuji Machida, Tatsuya Miyai, Hisataka Fujimori, Kouhei Morita, Manabu Nutrients Article Obesity induces gingival oxidative stress, which is involved in the progression of alveolar bone resorption. The antioxidant effect of hydrogen-rich water may attenuate gingival oxidative stress and prevent alveolar bone resorption in cases of obesity. We examined whether hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption in obese rats fed a high-fat diet. Male Fischer 344 rats (n = 18) were divided into three groups of six rats each: a control group (fed a regular diet and drinking distilled water) and two experimental groups (fed a high-fat diet and drinking distilled water or hydrogen-rich water). The level of 8-hydroxydeoxyguanosine was determined to evaluate oxidative stress. The bone mineral density of the alveolar bone was analyzed by micro-computerized tomography. Obese rats, induced by a high-fat diet, showed a higher gingival level of 8-hydroxydeoxyguanosine and a lower level of alveolar bone density compared to the control group. Drinking hydrogen-rich water suppressed body weight gain, lowered gingival level of 8-hydroxydeoxyguanosine, and reduced alveolar bone resorption in rats on a high-fat diet. The results indicate that hydrogen-rich water could suppress gingival oxidative stress and alveolar bone resorption by limiting obesity. MDPI 2017-01-13 /pmc/articles/PMC5295108/ /pubmed/28098768 http://dx.doi.org/10.3390/nu9010064 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yoneda, Toshiki
Tomofuji, Takaaki
Kunitomo, Muneyoshi
Ekuni, Daisuke
Irie, Koichiro
Azuma, Tetsuji
Machida, Tatsuya
Miyai, Hisataka
Fujimori, Kouhei
Morita, Manabu
Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title_full Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title_fullStr Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title_full_unstemmed Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title_short Preventive Effects of Drinking Hydrogen-Rich Water on Gingival Oxidative Stress and Alveolar Bone Resorption in Rats Fed a High-Fat Diet
title_sort preventive effects of drinking hydrogen-rich water on gingival oxidative stress and alveolar bone resorption in rats fed a high-fat diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295108/
https://www.ncbi.nlm.nih.gov/pubmed/28098768
http://dx.doi.org/10.3390/nu9010064
work_keys_str_mv AT yonedatoshiki preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT tomofujitakaaki preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT kunitomomuneyoshi preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT ekunidaisuke preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT iriekoichiro preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT azumatetsuji preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT machidatatsuya preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT miyaihisataka preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT fujimorikouhei preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet
AT moritamanabu preventiveeffectsofdrinkinghydrogenrichwaterongingivaloxidativestressandalveolarboneresorptioninratsfedahighfatdiet