Pyran Rings Containing Polyketides from Penicillium raistrickii

Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 a...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Li-Ying, Liu, De-Sheng, Li, De-Guo, Huang, Yu-Ling, Kang, Hui-Hui, Wang, Chun-Hua, Liu, Wei-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295222/
https://www.ncbi.nlm.nih.gov/pubmed/28025533
http://dx.doi.org/10.3390/md15010002
Descripción
Sumario:Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC(50) values of 4.4 and 8.5 μM, respectively.

Ejemplares similares