Pyran Rings Containing Polyketides from Penicillium raistrickii

Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 a...

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Autores principales: Ma, Li-Ying, Liu, De-Sheng, Li, De-Guo, Huang, Yu-Ling, Kang, Hui-Hui, Wang, Chun-Hua, Liu, Wei-Zhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295222/
https://www.ncbi.nlm.nih.gov/pubmed/28025533
http://dx.doi.org/10.3390/md15010002
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author Ma, Li-Ying
Liu, De-Sheng
Li, De-Guo
Huang, Yu-Ling
Kang, Hui-Hui
Wang, Chun-Hua
Liu, Wei-Zhong
author_facet Ma, Li-Ying
Liu, De-Sheng
Li, De-Guo
Huang, Yu-Ling
Kang, Hui-Hui
Wang, Chun-Hua
Liu, Wei-Zhong
author_sort Ma, Li-Ying
collection PubMed
description Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC(50) values of 4.4 and 8.5 μM, respectively.
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spelling pubmed-52952222017-02-07 Pyran Rings Containing Polyketides from Penicillium raistrickii Ma, Li-Ying Liu, De-Sheng Li, De-Guo Huang, Yu-Ling Kang, Hui-Hui Wang, Chun-Hua Liu, Wei-Zhong Mar Drugs Article Five new pyran rings containing polyketides, penicipyrans A–E (1–5), together with the known pestapyrone A (6), were isolated from the saline soil-derived Penicillium raistrickii. Their structures were determined by interpretation of NMR and HRESIMS data. The absolute configurations of compounds 4 and 5 were established by the modified Mosher’s method and single-crystal X-ray diffraction analysis, respectively. These compounds possessed high structural diversity including two α-pyrones (1, 2), three isocoumarins (3, 4, 6), and one dihydropyran derivative (5). Among them, Compound 5 exhibited cytotoxicity against HL-60 and K562 cell lines with IC(50) values of 4.4 and 8.5 μM, respectively. MDPI 2016-12-23 /pmc/articles/PMC5295222/ /pubmed/28025533 http://dx.doi.org/10.3390/md15010002 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Li-Ying
Liu, De-Sheng
Li, De-Guo
Huang, Yu-Ling
Kang, Hui-Hui
Wang, Chun-Hua
Liu, Wei-Zhong
Pyran Rings Containing Polyketides from Penicillium raistrickii
title Pyran Rings Containing Polyketides from Penicillium raistrickii
title_full Pyran Rings Containing Polyketides from Penicillium raistrickii
title_fullStr Pyran Rings Containing Polyketides from Penicillium raistrickii
title_full_unstemmed Pyran Rings Containing Polyketides from Penicillium raistrickii
title_short Pyran Rings Containing Polyketides from Penicillium raistrickii
title_sort pyran rings containing polyketides from penicillium raistrickii
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295222/
https://www.ncbi.nlm.nih.gov/pubmed/28025533
http://dx.doi.org/10.3390/md15010002
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