Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)

Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inh...

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Autores principales: Chang, Yu-Chia, Hwang, Tsong-Long, Kuo, Liang-Mou, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295231/
https://www.ncbi.nlm.nih.gov/pubmed/28067822
http://dx.doi.org/10.3390/md15010011
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author Chang, Yu-Chia
Hwang, Tsong-Long
Kuo, Liang-Mou
Sung, Ping-Jyun
author_facet Chang, Yu-Chia
Hwang, Tsong-Long
Kuo, Liang-Mou
Sung, Ping-Jyun
author_sort Chang, Yu-Chia
collection PubMed
description Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC(50) value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils.
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spelling pubmed-52952312017-02-07 Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae) Chang, Yu-Chia Hwang, Tsong-Long Kuo, Liang-Mou Sung, Ping-Jyun Mar Drugs Article Seven new marine 11-acetoxy-9,11-secosterols, pinnisterols D–J (1–7), with a 1,4-quinone moiety, were discovered from the gorgonian coral Pinnigorgia sp. In this study, the structures of secosterols 1–7 were revealed by spectroscopic analysis. Bioactivity study showed that secosterol 1 treatment inhibited cell viability in a hepatic stellate cell line, HSC-T6, with an IC(50) value of 3.93 μM; and secosterols 2, 5, and 7 reduced elastase enzyme release, and 3, 5, and 7 decreased the production of superoxide anions from human neutrophils. MDPI 2017-01-06 /pmc/articles/PMC5295231/ /pubmed/28067822 http://dx.doi.org/10.3390/md15010011 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chang, Yu-Chia
Hwang, Tsong-Long
Kuo, Liang-Mou
Sung, Ping-Jyun
Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_full Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_fullStr Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_full_unstemmed Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_short Pinnisterols D–J, New 11-Acetoxy-9,11-secosterols with a 1,4-Quinone Moiety from Formosan Gorgonian Coral Pinnigorgia sp. (Gorgoniidae)
title_sort pinnisterols d–j, new 11-acetoxy-9,11-secosterols with a 1,4-quinone moiety from formosan gorgonian coral pinnigorgia sp. (gorgoniidae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295231/
https://www.ncbi.nlm.nih.gov/pubmed/28067822
http://dx.doi.org/10.3390/md15010011
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