Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559

We address a methodological issue of the evaluation of the difference in effects in epidemiological studies that may arise, for example, from stratum-specific analyses or differences in analytical decisions during data analysis. We propose a new simulation-based method to quantify the plausible exte...

Descripción completa

Detalles Bibliográficos
Autores principales: Burstyn, Igor, De Roos, Anneclaire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295256/
https://www.ncbi.nlm.nih.gov/pubmed/28025514
http://dx.doi.org/10.3390/ijerph14010005
_version_ 1782505398205415424
author Burstyn, Igor
De Roos, Anneclaire J.
author_facet Burstyn, Igor
De Roos, Anneclaire J.
author_sort Burstyn, Igor
collection PubMed
description We address a methodological issue of the evaluation of the difference in effects in epidemiological studies that may arise, for example, from stratum-specific analyses or differences in analytical decisions during data analysis. We propose a new simulation-based method to quantify the plausible extent of such heterogeneity, rather than testing a hypothesis about its existence. We examine the contribution of the method to the debate surrounding risk of multiple myeloma and glyphosate use and propose that its application contributes to a more balanced weighting of evidence.
format Online
Article
Text
id pubmed-5295256
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-52952562017-02-07 Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559 Burstyn, Igor De Roos, Anneclaire J. Int J Environ Res Public Health Comment We address a methodological issue of the evaluation of the difference in effects in epidemiological studies that may arise, for example, from stratum-specific analyses or differences in analytical decisions during data analysis. We propose a new simulation-based method to quantify the plausible extent of such heterogeneity, rather than testing a hypothesis about its existence. We examine the contribution of the method to the debate surrounding risk of multiple myeloma and glyphosate use and propose that its application contributes to a more balanced weighting of evidence. MDPI 2016-12-22 2017-01 /pmc/articles/PMC5295256/ /pubmed/28025514 http://dx.doi.org/10.3390/ijerph14010005 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Comment
Burstyn, Igor
De Roos, Anneclaire J.
Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title_full Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title_fullStr Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title_full_unstemmed Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title_short Visualizing the Heterogeneity of Effects in the Analysis of Associations of Multiple Myeloma with Glyphosate Use. Comments on Sorahan, T. Multiple Myeloma and Glyphosate Use: A Re-Analysis of US Agricultural Health Study (AHS) Data. Int. J. Environ. Res. Public Health 2015, 12, 1548–1559
title_sort visualizing the heterogeneity of effects in the analysis of associations of multiple myeloma with glyphosate use. comments on sorahan, t. multiple myeloma and glyphosate use: a re-analysis of us agricultural health study (ahs) data. int. j. environ. res. public health 2015, 12, 1548–1559
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295256/
https://www.ncbi.nlm.nih.gov/pubmed/28025514
http://dx.doi.org/10.3390/ijerph14010005
work_keys_str_mv AT burstynigor visualizingtheheterogeneityofeffectsintheanalysisofassociationsofmultiplemyelomawithglyphosateusecommentsonsorahantmultiplemyelomaandglyphosateuseareanalysisofusagriculturalhealthstudyahsdataintjenvironrespublichealth20151215481559
AT deroosanneclairej visualizingtheheterogeneityofeffectsintheanalysisofassociationsofmultiplemyelomawithglyphosateusecommentsonsorahantmultiplemyelomaandglyphosateuseareanalysisofusagriculturalhealthstudyahsdataintjenvironrespublichealth20151215481559

Ejemplares similares