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Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome

To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral foll...

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Autores principales: Zhou, Wei, Fang, Fang, Zhu, Wenting, Chen, Zi-Jiang, Du, Yanzhi, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295269/
https://www.ncbi.nlm.nih.gov/pubmed/28036005
http://dx.doi.org/10.3390/ijerph14010018
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author Zhou, Wei
Fang, Fang
Zhu, Wenting
Chen, Zi-Jiang
Du, Yanzhi
Zhang, Jun
author_facet Zhou, Wei
Fang, Fang
Zhu, Wenting
Chen, Zi-Jiang
Du, Yanzhi
Zhang, Jun
author_sort Zhou, Wei
collection PubMed
description To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = −0.34, 95% CI = −0.60, −0.08; p = 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve.
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spelling pubmed-52952692017-02-07 Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome Zhou, Wei Fang, Fang Zhu, Wenting Chen, Zi-Jiang Du, Yanzhi Zhang, Jun Int J Environ Res Public Health Article To better understand possible effects of bisphenol A (BPA) exposure on ovarian reserve in women with polycystic ovary syndrome (PCOS), we measured creatinine adjusted urinary BPA (BPA_Cre) concentrations and used regression models to evaluate the association between urinary BPA level and antral follicle count (AFC), antimullerian hormone (AMH), day-3 follicle stimulating hormone levels (FSH) and inhibin B (INHB) in 268 infertile women diagnosed with PCOS. BPA was detected in all women with a median concentration of 2.35 ng/mL (the 25th and 75th percentiles of 1.47 ng/mL and 3.95 ng/mL). A unit increase in BPA_Cre was associated with a significant decrease of 0.34 in AFC (β = −0.34, 95% CI = −0.60, −0.08; p = 0.01). Likewise, BPA was negatively associated with AMH and day-3 FSH levels, but neither of them reached statistical significance. No association was observed between BPA and INHB. Our results suggest that in women with PCOS, BPA may affect ovarian follicles and, therefore, reduce ovarian reserve. MDPI 2016-12-27 2017-01 /pmc/articles/PMC5295269/ /pubmed/28036005 http://dx.doi.org/10.3390/ijerph14010018 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhou, Wei
Fang, Fang
Zhu, Wenting
Chen, Zi-Jiang
Du, Yanzhi
Zhang, Jun
Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title_full Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title_fullStr Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title_full_unstemmed Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title_short Bisphenol A and Ovarian Reserve among Infertile Women with Polycystic Ovarian Syndrome
title_sort bisphenol a and ovarian reserve among infertile women with polycystic ovarian syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295269/
https://www.ncbi.nlm.nih.gov/pubmed/28036005
http://dx.doi.org/10.3390/ijerph14010018
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