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Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China

Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential ta...

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Autores principales: Wang, Zhifang, Lv, Huakun, Zhu, Wenming, Mo, Zhe, Mao, Guangming, Wang, Xiaofeng, Lou, Xiaoming, Chen, Yongdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295284/
https://www.ncbi.nlm.nih.gov/pubmed/28042848
http://dx.doi.org/10.3390/ijerph14010033
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author Wang, Zhifang
Lv, Huakun
Zhu, Wenming
Mo, Zhe
Mao, Guangming
Wang, Xiaofeng
Lou, Xiaoming
Chen, Yongdi
author_facet Wang, Zhifang
Lv, Huakun
Zhu, Wenming
Mo, Zhe
Mao, Guangming
Wang, Xiaofeng
Lou, Xiaoming
Chen, Yongdi
author_sort Wang, Zhifang
collection PubMed
description Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance. We extracted data on EV71-associated HFMD from the National Notifiable Disease Reporting System in Zhejiang Province, China between 1 January 2009 and 31 December 2013 (n = 7650). The higher incidence rate of EV71 cases occurred in those children aged 12–23 months, with boys being predominant. Interestingly, different peaks activities of EV71 infection was observed in different calendar year, with one peak in 2009 and 2013 and two peaks in 2010–2012. However, EV71 infection seemed to predominately occur in warm season and a distinguished cyclic peak that seemed to be of about 12 months. Children aged 12–23 months are thus identified as an important target population for public health intervention, for example, it is recommended that these key subjects immunized with EV71 vaccine. In addition, an enhanced surveillance system for EV71-associated with HFMD needs to focus on generic and phylogenetic analysis.
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spelling pubmed-52952842017-02-07 Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China Wang, Zhifang Lv, Huakun Zhu, Wenming Mo, Zhe Mao, Guangming Wang, Xiaofeng Lou, Xiaoming Chen, Yongdi Int J Environ Res Public Health Article Enterovirus 71 (EV71) usually causes hand-foot-and-mouth disease (HFMD) with severe clinical symptoms and even deaths in China. There is no efficient antiviral drug to protect against severe EV71-associated HFMD, making the development of EV71 vaccines therefore a priority. However, the potential target subject population(s) to be immunized with EV71 vaccine are not well understood. In this study, we characterized the epidemiology regarding EV71-associated HFMD on the basis of provincial-level surveillance. We extracted data on EV71-associated HFMD from the National Notifiable Disease Reporting System in Zhejiang Province, China between 1 January 2009 and 31 December 2013 (n = 7650). The higher incidence rate of EV71 cases occurred in those children aged 12–23 months, with boys being predominant. Interestingly, different peaks activities of EV71 infection was observed in different calendar year, with one peak in 2009 and 2013 and two peaks in 2010–2012. However, EV71 infection seemed to predominately occur in warm season and a distinguished cyclic peak that seemed to be of about 12 months. Children aged 12–23 months are thus identified as an important target population for public health intervention, for example, it is recommended that these key subjects immunized with EV71 vaccine. In addition, an enhanced surveillance system for EV71-associated with HFMD needs to focus on generic and phylogenetic analysis. MDPI 2016-12-30 2017-01 /pmc/articles/PMC5295284/ /pubmed/28042848 http://dx.doi.org/10.3390/ijerph14010033 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Zhifang
Lv, Huakun
Zhu, Wenming
Mo, Zhe
Mao, Guangming
Wang, Xiaofeng
Lou, Xiaoming
Chen, Yongdi
Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title_full Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title_fullStr Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title_full_unstemmed Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title_short Epidemiologic Features of Enterovirus 71-Associated Hand-Foot-and-Mouth Disease from 2009 to 2013 in Zhejiang, China
title_sort epidemiologic features of enterovirus 71-associated hand-foot-and-mouth disease from 2009 to 2013 in zhejiang, china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295284/
https://www.ncbi.nlm.nih.gov/pubmed/28042848
http://dx.doi.org/10.3390/ijerph14010033
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