Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors

MYC oncoproteins deliver a potent oncogenic stimulus in several human cancers, making them major targets for drug development, but efforts to deliver clinically practical therapeutics have not yet been realized. In childhood cancer, aberrant expression of MYC and MYCN genes delineates a group of agg...

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Detalles Bibliográficos
Autores principales: Vaughan, Lynsey, Clarke, Paul A., Barker, Karen, Chanthery, Yvan, Gustafson, Clay W., Tucker, Elizabeth, Renshaw, Jane, Raynaud, Florence, Li, Xiaodun, Burke, Rosemary, Jamin, Yann, Robinson, Simon P., Pearson, Andrew, Maira, Michel, Weiss, William A., Workman, Paul, Chesler, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295370/
https://www.ncbi.nlm.nih.gov/pubmed/27438153
http://dx.doi.org/10.18632/oncotarget.10544

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