A recombinantly tailored β-defensin that displays intensive macropinocytosis-mediated uptake exerting potent efficacy against K-Ras mutant pancreatic cancer

K-Ras mutant pancreatic cancer cells display intensive macropinocytosis, indicating that this process may be exploited in the design of anticancer targeted therapies. In this study, we constructed a macropinocytosis-oriented recombinantly tailored defensin (DF-HSA) which consists of human β-defensin...

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Detalles Bibliográficos
Autores principales: Du, Yue, Shang, Bo-yang, Sheng, Wei-jin, Zhang, Sheng-hua, Li, Yi, Miao, Qing-fang, Zhen, Yong-su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295440/
https://www.ncbi.nlm.nih.gov/pubmed/27517152
http://dx.doi.org/10.18632/oncotarget.11170

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