An updated meta-analysis of 37 case-control studies on the association between NFKB1 −94ins/del ATTG promoter polymorphism and cancer susceptibility

As a cell survival signal, nuclear factor-kappa B (NFKB) is associated with the pathogenesis of numerous malignancies. According to several studies, NFKB1 −94ins/del ATTG promoter polymorphism is associated with the risk of different malignancies, but the results were not consistent. Therefore, we performed an updated meta-analysis based on 37 case-control studies from 33 articles (16,271 cases and 22,781 controls) to clarify the relationship. The odds ratio (OR) and 95% confidence interval (CI) were used to determine the strength of the association. We found that the NFKB1 −94ins/del ATTG promoter polymorphism was significantly associated with increased susceptibility to cancer in the recessive (II vs. ID+DD, OR = 1.140, 95% CI = 1.029–1.263, p =0.012), homozygote (II vs. DD, OR = 1.259, 95% CI = 1.068–1.485, p =0.006), and allele (I vs. D, OR = 1.109, 95% CI = 1.025–1.199, p =0.010) genetic models. The subgroup analysis for ethnicity found that the NFKB1 −94ins/del ATTG promoter polymorphism was significantly associated with an increased susceptibility to cancer in Asians and with a decreased susceptibility in Caucasians. The stratified analyses revealed significant associations between the polymorphism and increased susceptibility to ovarian cancer, oral squamous cell carcinoma, and nasopharyngeal carcinoma.