Cargando…
TNFα alters occludin and cerebral endothelial permeability: Role of p38MAPK
Occludin is a key tight junction (TJ) protein in cerebral endothelial cells (CECs) playing an important role in modulating blood-brain barrier (BBB) functions. This protein (65kDa) has been shown to engage in many signaling pathways and phosphorylation by both tyrosine and threonine kinases. Despite...
Autores principales: | Ni, Yawen, Teng, Tao, Li, Runting, Simonyi, Agnes, Sun, Grace Y., Lee, James C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295672/ https://www.ncbi.nlm.nih.gov/pubmed/28170408 http://dx.doi.org/10.1371/journal.pone.0170346 |
Ejemplares similares
-
Amyloid-β-induced occludin down-regulation and increased permeability in human brain endothelial cells is mediated by MAPK activation
por: Tai, L M, et al.
Publicado: (2010) -
PHD3 inhibits colon cancer cell metastasis through the occludin-p38 pathway: PHD3 inhibits metastasis via occludin-p38 MAPK
por: Li, Yuyao, et al.
Publicado: (2023) -
TNF-α promotes human antibody-mediated complement-dependent cytotoxicity of porcine endothelial cells through downregulating P38-mediated Occludin expression
por: Gao, Hanchao, et al.
Publicado: (2019) -
LPS Induces Occludin Dysregulation in Cerebral Microvascular Endothelial Cells via MAPK Signaling and Augmenting MMP-2 Levels
por: Qin, Lan-hui, et al.
Publicado: (2015) -
Cadmium regulates von Willebrand factor and occludin expression in glomerular endothelial cells of mice in a TNF-α-dependent manner
por: Sun, Zongguo, et al.
Publicado: (2019)