Interleukin-10–mediated regenerative postnatal tissue repair is dependent on regulation of hyaluronan metabolism via fibroblast-specific STAT3 signaling

The cytokine IL-10 has potent antifibrotic effects in models of adult fibrosis, but the mechanisms of action are unclear. Here, we report a novel finding that IL-10 triggers a signal transducer and activator of transcription 3 (STAT3)–dependent signaling pathway that regulates hyaluronan (HA) metabo...

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Detalles Bibliográficos
Autores principales: Balaji, Swathi, Wang, Xinyi, King, Alice, Le, Louis D., Bhattacharya, Sukanta S., Moles, Chad M., Butte, Manish J., de Jesus Perez, Vinicio A., Liechty, Kenneth W., Wight, Thomas N., Crombleholme, Timothy M., Bollyky, Paul L., Keswani, Sundeep G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Federation of American Societies for Experimental Biology 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295728/
https://www.ncbi.nlm.nih.gov/pubmed/27903619
http://dx.doi.org/10.1096/fj.201600856R

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