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Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer
Background: Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295775/ https://www.ncbi.nlm.nih.gov/pubmed/28067809 http://dx.doi.org/10.3390/cancers9010004 |
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author | Asano, Yuka Kashiwagi, Shinichiro Goto, Wataru Tanaka, Sayaka Morisaki, Tamami Takashima, Tsutomu Noda, Satoru Onoda, Naoyoshi Ohsawa, Masahiko Hirakawa, Kosei Ohira, Masaichi |
author_facet | Asano, Yuka Kashiwagi, Shinichiro Goto, Wataru Tanaka, Sayaka Morisaki, Tamami Takashima, Tsutomu Noda, Satoru Onoda, Naoyoshi Ohsawa, Masahiko Hirakawa, Kosei Ohira, Masaichi |
author_sort | Asano, Yuka |
collection | PubMed |
description | Background: Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clinicopathologic features in TNBC. Methods: This study investigated 1036 cases of sporadic invasive breast carcinoma. Immunohistochemical assays were performed to determine the expression of AR in 190 TNBC samples. The relationships between AR expression and clinicopathologic data and prognosis were analyzed. Results: In 190 TNBC cases, the prognosis of AR-positive patients was significantly better (p = 0.019, log-rank) than AR-negative patients, and in multivariate analysis, AR expression was an independent indicator of good prognosis (p = 0.039, hazard ratio = 0.36). In patients with disease relapse, AR positivity was significantly correlated with better prognosis (p = 0.034, log-rank). Conclusions: AR expression may be useful as a subclassification marker for prognosis in TNBC. |
format | Online Article Text |
id | pubmed-5295775 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-52957752017-02-08 Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer Asano, Yuka Kashiwagi, Shinichiro Goto, Wataru Tanaka, Sayaka Morisaki, Tamami Takashima, Tsutomu Noda, Satoru Onoda, Naoyoshi Ohsawa, Masahiko Hirakawa, Kosei Ohira, Masaichi Cancers (Basel) Article Background: Triple-negative breast cancer (TNBC) has a poor prognosis because of frequent recurrence. Androgen receptor (AR) is involved in the pathogenesis of breast cancer, but its role is not clearly defined. The aim of this study was to explore the expression of AR and its relationship with clinicopathologic features in TNBC. Methods: This study investigated 1036 cases of sporadic invasive breast carcinoma. Immunohistochemical assays were performed to determine the expression of AR in 190 TNBC samples. The relationships between AR expression and clinicopathologic data and prognosis were analyzed. Results: In 190 TNBC cases, the prognosis of AR-positive patients was significantly better (p = 0.019, log-rank) than AR-negative patients, and in multivariate analysis, AR expression was an independent indicator of good prognosis (p = 0.039, hazard ratio = 0.36). In patients with disease relapse, AR positivity was significantly correlated with better prognosis (p = 0.034, log-rank). Conclusions: AR expression may be useful as a subclassification marker for prognosis in TNBC. MDPI 2017-01-06 /pmc/articles/PMC5295775/ /pubmed/28067809 http://dx.doi.org/10.3390/cancers9010004 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Asano, Yuka Kashiwagi, Shinichiro Goto, Wataru Tanaka, Sayaka Morisaki, Tamami Takashima, Tsutomu Noda, Satoru Onoda, Naoyoshi Ohsawa, Masahiko Hirakawa, Kosei Ohira, Masaichi Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title | Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title_full | Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title_fullStr | Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title_full_unstemmed | Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title_short | Expression and Clinical Significance of Androgen Receptor in Triple-Negative Breast Cancer |
title_sort | expression and clinical significance of androgen receptor in triple-negative breast cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295775/ https://www.ncbi.nlm.nih.gov/pubmed/28067809 http://dx.doi.org/10.3390/cancers9010004 |
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