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Bone Morphogenetic Protein-7 Suppresses TGFβ2-Induced Epithelial-Mesenchymal Transition in the Lens: Implications for Cataract Prevention

PURPOSE: Epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) is a key pathologic mechanism underlying cataract. Two members of the transforming growth factor-β (TGFβ) superfamily, TGFβ and bone morphogenetic protein-7 (BMP-7) have functionally distinct roles in EMT. While TGFβ is...

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Detalles Bibliográficos
Autores principales:	Shu, Daisy Y., Wojciechowski, Magdalena C., Lovicu, Frank J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2017
Materias:	Lens
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295783/ https://www.ncbi.nlm.nih.gov/pubmed/28152139 http://dx.doi.org/10.1167/iovs.16-20611

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