Loss of μ-opioid receptor signaling in nociceptors, and not spinal microglia, abrogates morphine tolerance without disrupting analgesic efficacy

Opioid pain medications cause detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). Tolerance and OIH counteract opioid analgesia, and drive dose escalation. The cell-types and receptors on which opioids act to initiate these maladaptive processes remain dispu...

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Detalles Bibliográficos
Autores principales: Corder, Gregory, Tawfik, Vivianne L., Wang, Dong, Sypek, Elizabeth I., Low, Sarah A., Dickinson, Jasmine R., Sotoudeh, Chaudy, Clark, J. David, Barres, Ben A., Bohlen, Christopher J., Scherrer, Grégory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296291/
https://www.ncbi.nlm.nih.gov/pubmed/28092666
http://dx.doi.org/10.1038/nm.4262

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