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From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective

The adrenocorticotropic hormone (ACTH) is a pituitary hormone derived from a larger peptide, the proopiomelanocortin (POMC), as are the MSHs (α-MSH, β-MSH, and γ-MSH) and the β-LPH-related polypeptides (Figure 1A). ACTH drives adrenal steroidogenesis and growth of the adrenal gland. ACTH is a 39 ami...

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Autores principales: Ghaddhab, Chiraz, Vuissoz, Jean-Marc, Deladoëy, Johnny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296294/
https://www.ncbi.nlm.nih.gov/pubmed/28228747
http://dx.doi.org/10.3389/fendo.2017.00017
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author Ghaddhab, Chiraz
Vuissoz, Jean-Marc
Deladoëy, Johnny
author_facet Ghaddhab, Chiraz
Vuissoz, Jean-Marc
Deladoëy, Johnny
author_sort Ghaddhab, Chiraz
collection PubMed
description The adrenocorticotropic hormone (ACTH) is a pituitary hormone derived from a larger peptide, the proopiomelanocortin (POMC), as are the MSHs (α-MSH, β-MSH, and γ-MSH) and the β-LPH-related polypeptides (Figure 1A). ACTH drives adrenal steroidogenesis and growth of the adrenal gland. ACTH is a 39 amino acid polypeptide that binds and activates its cognate receptor [melanocortin receptor 2 (MC2R)] through the two regions H(6)F(7)R(8)W(9) and K(15)K(16)R(17)R(18)P(19). Most POMC-derived polypeptides contain the H(6)F(7)R(8)W(9) sequence that is conserved through evolution. This explains the difficulties in developing selective agonists or antagonists to the MCRs. In this review, we will discuss the clinical aspects of the role of ACTH in physiology and disease, and potential clinical use of selective ACTH antagonists.
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spelling pubmed-52962942017-02-22 From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective Ghaddhab, Chiraz Vuissoz, Jean-Marc Deladoëy, Johnny Front Endocrinol (Lausanne) Endocrinology The adrenocorticotropic hormone (ACTH) is a pituitary hormone derived from a larger peptide, the proopiomelanocortin (POMC), as are the MSHs (α-MSH, β-MSH, and γ-MSH) and the β-LPH-related polypeptides (Figure 1A). ACTH drives adrenal steroidogenesis and growth of the adrenal gland. ACTH is a 39 amino acid polypeptide that binds and activates its cognate receptor [melanocortin receptor 2 (MC2R)] through the two regions H(6)F(7)R(8)W(9) and K(15)K(16)R(17)R(18)P(19). Most POMC-derived polypeptides contain the H(6)F(7)R(8)W(9) sequence that is conserved through evolution. This explains the difficulties in developing selective agonists or antagonists to the MCRs. In this review, we will discuss the clinical aspects of the role of ACTH in physiology and disease, and potential clinical use of selective ACTH antagonists. Frontiers Media S.A. 2017-02-08 /pmc/articles/PMC5296294/ /pubmed/28228747 http://dx.doi.org/10.3389/fendo.2017.00017 Text en Copyright © 2017 Ghaddhab, Vuissoz and Deladoëy. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ghaddhab, Chiraz
Vuissoz, Jean-Marc
Deladoëy, Johnny
From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title_full From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title_fullStr From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title_full_unstemmed From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title_short From Bioinactive ACTH to ACTH Antagonist: The Clinical Perspective
title_sort from bioinactive acth to acth antagonist: the clinical perspective
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296294/
https://www.ncbi.nlm.nih.gov/pubmed/28228747
http://dx.doi.org/10.3389/fendo.2017.00017
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