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Agonistic Anti-PDGF Receptor Autoantibodies from Patients with Systemic Sclerosis Impact Human Pulmonary Artery Smooth Muscle Cells Function In Vitro

One of the earliest events in the pathogenesis of systemic sclerosis (SSc) is microvasculature damage with intimal hyperplasia and accumulation of cells expressing PDGF receptor. Stimulatory autoantibodies targeting PDGF receptor have been detected in SSc patients and demonstrated to induce fibrosis...

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Detalles Bibliográficos
Autores principales:	Svegliati, Silvia, Amico, Donatella, Spadoni, Tatiana, Fischetti, Colomba, Finke, Doreen, Moroncini, Gianluca, Paolini, Chiara, Tonnini, Cecilia, Grieco, Antonella, Rovinelli, Marina, Funaro, Ada, Gabrielli, Armando
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296309/ https://www.ncbi.nlm.nih.gov/pubmed/28228756 http://dx.doi.org/10.3389/fimmu.2017.00075

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