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Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes

Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the...

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Autores principales: Jończyk-Matysiak, Ewa, Weber-Dąbrowska, Beata, Żaczek, Maciej, Międzybrodzki, Ryszard, Letkiewicz, Sławomir, Łusiak-Szelchowska, Marzanna, Górski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296327/
https://www.ncbi.nlm.nih.gov/pubmed/28228751
http://dx.doi.org/10.3389/fmicb.2017.00164
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author Jończyk-Matysiak, Ewa
Weber-Dąbrowska, Beata
Żaczek, Maciej
Międzybrodzki, Ryszard
Letkiewicz, Sławomir
Łusiak-Szelchowska, Marzanna
Górski, Andrzej
author_facet Jończyk-Matysiak, Ewa
Weber-Dąbrowska, Beata
Żaczek, Maciej
Międzybrodzki, Ryszard
Letkiewicz, Sławomir
Łusiak-Szelchowska, Marzanna
Górski, Andrzej
author_sort Jończyk-Matysiak, Ewa
collection PubMed
description Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment. In this review, we have summarized the current knowledge on the phages active against P. acnes described so far and their potential application in the treatment of acne associated with P. acnes. The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment. However, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat P. acnes.
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spelling pubmed-52963272017-02-22 Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes Jończyk-Matysiak, Ewa Weber-Dąbrowska, Beata Żaczek, Maciej Międzybrodzki, Ryszard Letkiewicz, Sławomir Łusiak-Szelchowska, Marzanna Górski, Andrzej Front Microbiol Microbiology Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment. In this review, we have summarized the current knowledge on the phages active against P. acnes described so far and their potential application in the treatment of acne associated with P. acnes. The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment. However, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat P. acnes. Frontiers Media S.A. 2017-02-08 /pmc/articles/PMC5296327/ /pubmed/28228751 http://dx.doi.org/10.3389/fmicb.2017.00164 Text en Copyright © 2017 Jończyk-Matysiak, Weber-Dąbrowska, Żaczek, Międzybrodzki, Letkiewicz, Łusiak-Szelchowska and Górski. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Jończyk-Matysiak, Ewa
Weber-Dąbrowska, Beata
Żaczek, Maciej
Międzybrodzki, Ryszard
Letkiewicz, Sławomir
Łusiak-Szelchowska, Marzanna
Górski, Andrzej
Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title_full Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title_fullStr Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title_full_unstemmed Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title_short Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
title_sort prospects of phage application in the treatment of acne caused by propionibacterium acnes
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296327/
https://www.ncbi.nlm.nih.gov/pubmed/28228751
http://dx.doi.org/10.3389/fmicb.2017.00164
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