Cargando…
Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes
Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296327/ https://www.ncbi.nlm.nih.gov/pubmed/28228751 http://dx.doi.org/10.3389/fmicb.2017.00164 |
_version_ | 1782505582798831616 |
---|---|
author | Jończyk-Matysiak, Ewa Weber-Dąbrowska, Beata Żaczek, Maciej Międzybrodzki, Ryszard Letkiewicz, Sławomir Łusiak-Szelchowska, Marzanna Górski, Andrzej |
author_facet | Jończyk-Matysiak, Ewa Weber-Dąbrowska, Beata Żaczek, Maciej Międzybrodzki, Ryszard Letkiewicz, Sławomir Łusiak-Szelchowska, Marzanna Górski, Andrzej |
author_sort | Jończyk-Matysiak, Ewa |
collection | PubMed |
description | Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment. In this review, we have summarized the current knowledge on the phages active against P. acnes described so far and their potential application in the treatment of acne associated with P. acnes. The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment. However, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat P. acnes. |
format | Online Article Text |
id | pubmed-5296327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52963272017-02-22 Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes Jończyk-Matysiak, Ewa Weber-Dąbrowska, Beata Żaczek, Maciej Międzybrodzki, Ryszard Letkiewicz, Sławomir Łusiak-Szelchowska, Marzanna Górski, Andrzej Front Microbiol Microbiology Propionibacterium acnes is associated with purulent skin infections, and it poses a global problem for both patients and doctors. Acne vulgaris (acne) remains a problem due to its chronic character and difficulty of treatment, as well as its large impact on patients' quality of life. Due to the chronic course of the disease, treatment is long lasting, and often ineffective. Currently there are data regarding isolation of P. acnes phages, and there have been numerous studies on phage killing of P. acnes, but no data are available on phage application specifically in acne treatment. In this review, we have summarized the current knowledge on the phages active against P. acnes described so far and their potential application in the treatment of acne associated with P. acnes. The treatment of acne with phages may be important in order to reduce the overuse of antibiotics, which are currently the main acne treatment. However, more detailed studies are first needed to understand phage functioning in the skin microbiome and the possibility to use phages to combat P. acnes. Frontiers Media S.A. 2017-02-08 /pmc/articles/PMC5296327/ /pubmed/28228751 http://dx.doi.org/10.3389/fmicb.2017.00164 Text en Copyright © 2017 Jończyk-Matysiak, Weber-Dąbrowska, Żaczek, Międzybrodzki, Letkiewicz, Łusiak-Szelchowska and Górski. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Jończyk-Matysiak, Ewa Weber-Dąbrowska, Beata Żaczek, Maciej Międzybrodzki, Ryszard Letkiewicz, Sławomir Łusiak-Szelchowska, Marzanna Górski, Andrzej Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title | Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title_full | Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title_fullStr | Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title_full_unstemmed | Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title_short | Prospects of Phage Application in the Treatment of Acne Caused by Propionibacterium acnes |
title_sort | prospects of phage application in the treatment of acne caused by propionibacterium acnes |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296327/ https://www.ncbi.nlm.nih.gov/pubmed/28228751 http://dx.doi.org/10.3389/fmicb.2017.00164 |
work_keys_str_mv | AT jonczykmatysiakewa prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT weberdabrowskabeata prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT zaczekmaciej prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT miedzybrodzkiryszard prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT letkiewiczsławomir prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT łusiakszelchowskamarzanna prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes AT gorskiandrzej prospectsofphageapplicationinthetreatmentofacnecausedbypropionibacteriumacnes |