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Dysregulation of SOCS-Mediated Negative Feedback of Cytokine Signaling in Carcinogenesis and Its Significance in Cancer Treatment

Suppressor of cytokine signaling (SOCS) proteins are major negative feedback regulators of cytokine signaling mediated by the Janus kinase (JAK)-signal transducer and activator of transcription signaling pathway. In particular, SOCS1 and SOCS3 are strong inhibitors of JAKs and can play pivotal roles...

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Detalles Bibliográficos
Autores principales:	Jiang, Mengmeng, Zhang, Wen-wen, Liu, Pengpeng, Yu, Wenwen, Liu, Ting, Yu, Jinpu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296614/ https://www.ncbi.nlm.nih.gov/pubmed/28228755 http://dx.doi.org/10.3389/fimmu.2017.00070

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