β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions

β-arrestins are critical signalling molecules that regulate many fundamental physiological functions including the maintenance of euglycemia and peripheral insulin sensitivity. Here we show that inactivation of the β-arrestin-2 gene, barr2, in β-cells of adult mice greatly impairs insulin release an...

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Detalles Bibliográficos
Autores principales: Zhu, Lu, Almaça, Joana, Dadi, Prasanna K., Hong, Hao, Sakamoto, Wataru, Rossi, Mario, Lee, Regina J., Vierra, Nicholas C., Lu, Huiyan, Cui, Yinghong, McMillin, Sara M., Perry, Nicole A., Gurevich, Vsevolod V., Lee, Amy, Kuo, Bryan, Leapman, Richard D., Matschinsky, Franz M., Doliba, Nicolai M., Urs, Nikhil M., Caron, Marc G., Jacobson, David A., Caicedo, Alejandro, Wess, Jürgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296650/
https://www.ncbi.nlm.nih.gov/pubmed/28145434
http://dx.doi.org/10.1038/ncomms14295

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