Functional Coupling of Human Microphysiology Systems: Intestine, Liver, Kidney Proximal Tubule, Blood-Brain Barrier and Skeletal Muscle

Organ interactions resulting from drug, metabolite or xenobiotic transport between organs are key components of human metabolism that impact therapeutic action and toxic side effects. Preclinical animal testing often fails to predict adverse outcomes arising from sequential, multi-organ metabolism o...

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Detalles Bibliográficos
Autores principales: Vernetti, Lawrence, Gough, Albert, Baetz, Nicholas, Blutt, Sarah, Broughman, James R., Brown, Jacquelyn A., Foulke-Abel, Jennifer, Hasan, Nesrin, In, Julie, Kelly, Edward, Kovbasnjuk, Olga, Repper, Jonathan, Senutovitch, Nina, Stabb, Janet, Yeung, Catherine, Zachos, Nick C., Donowitz, Mark, Estes, Mary, Himmelfarb, Jonathan, Truskey, George, Wikswo, John P., Taylor, D. Lansing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296733/
https://www.ncbi.nlm.nih.gov/pubmed/28176881
http://dx.doi.org/10.1038/srep42296

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