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Structural white matter and functional connectivity alterations in patients with shoulder apprehension

Previous functional magnetic resonance imaging (fMRI) findings indicate that shoulder apprehension is more complex than a pure mechanical problem of the shoulder, showing a direct modification in functional brain networks associated with motor inhibition and emotional regulation. The current study e...

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Autores principales: Zanchi, Davide, Cunningham, Gregory, Lädermann, Alexandre, Ozturk, Mehmet, Hoffmeyer, Pierre, Haller, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296739/
https://www.ncbi.nlm.nih.gov/pubmed/28176877
http://dx.doi.org/10.1038/srep42327
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author Zanchi, Davide
Cunningham, Gregory
Lädermann, Alexandre
Ozturk, Mehmet
Hoffmeyer, Pierre
Haller, Sven
author_facet Zanchi, Davide
Cunningham, Gregory
Lädermann, Alexandre
Ozturk, Mehmet
Hoffmeyer, Pierre
Haller, Sven
author_sort Zanchi, Davide
collection PubMed
description Previous functional magnetic resonance imaging (fMRI) findings indicate that shoulder apprehension is more complex than a pure mechanical problem of the shoulder, showing a direct modification in functional brain networks associated with motor inhibition and emotional regulation. The current study extends these findings by investigating further structural alterations in patients with shoulder apprehension compared to controls. 14 aged patients with shoulder apprehension (27.3 ± 2.0 years) and 10 matched healthy controls (29.6 ± 1.3 years) underwent clinical and fMRI examination including fMRI and diffusion tensor imaging (DTI). Tract-based spatial statistics procedure was used to analyze white matter (WM) alterations. Functional images were analyzed investigating resting state network connectivity. DTI results were correlated with different shoulder clinical scores and functional connectivity networks. Fractional anisotropy (FA), representing white matter integrity, is increased in the left internal capsule and partially in the thalamus in patients compared to controls. Moreover, FA correlates negatively with simple shoulder test (SST) scores (p < .05) and positively with a functional connectivity network qualitatively replicating previous results (p < .01). This study extends previous findings, showing that in addition to functional changes, structural white matter changes are also present in patients with shoulder apprehension.
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spelling pubmed-52967392017-02-10 Structural white matter and functional connectivity alterations in patients with shoulder apprehension Zanchi, Davide Cunningham, Gregory Lädermann, Alexandre Ozturk, Mehmet Hoffmeyer, Pierre Haller, Sven Sci Rep Article Previous functional magnetic resonance imaging (fMRI) findings indicate that shoulder apprehension is more complex than a pure mechanical problem of the shoulder, showing a direct modification in functional brain networks associated with motor inhibition and emotional regulation. The current study extends these findings by investigating further structural alterations in patients with shoulder apprehension compared to controls. 14 aged patients with shoulder apprehension (27.3 ± 2.0 years) and 10 matched healthy controls (29.6 ± 1.3 years) underwent clinical and fMRI examination including fMRI and diffusion tensor imaging (DTI). Tract-based spatial statistics procedure was used to analyze white matter (WM) alterations. Functional images were analyzed investigating resting state network connectivity. DTI results were correlated with different shoulder clinical scores and functional connectivity networks. Fractional anisotropy (FA), representing white matter integrity, is increased in the left internal capsule and partially in the thalamus in patients compared to controls. Moreover, FA correlates negatively with simple shoulder test (SST) scores (p < .05) and positively with a functional connectivity network qualitatively replicating previous results (p < .01). This study extends previous findings, showing that in addition to functional changes, structural white matter changes are also present in patients with shoulder apprehension. Nature Publishing Group 2017-02-08 /pmc/articles/PMC5296739/ /pubmed/28176877 http://dx.doi.org/10.1038/srep42327 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zanchi, Davide
Cunningham, Gregory
Lädermann, Alexandre
Ozturk, Mehmet
Hoffmeyer, Pierre
Haller, Sven
Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title_full Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title_fullStr Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title_full_unstemmed Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title_short Structural white matter and functional connectivity alterations in patients with shoulder apprehension
title_sort structural white matter and functional connectivity alterations in patients with shoulder apprehension
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296739/
https://www.ncbi.nlm.nih.gov/pubmed/28176877
http://dx.doi.org/10.1038/srep42327
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