Engineering a pH responsive pore forming protein

Listeriolysin O (LLO) is a cytolysin capable of forming pores in cholesterol-rich lipid membranes of host cells. It is conveniently suited for engineering a pH-governed responsiveness, due to a pH sensor identified in its structure that was shown before to affect its stability. Here we introduced a...

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Detalles Bibliográficos
Autores principales: Kisovec, Matic, Rezelj, Saša, Knap, Primož, Cajnko, Miša Mojca, Caserman, Simon, Flašker, Ajda, Žnidaršič, Nada, Repič, Matej, Mavri, Janez, Ruan, Yi, Scheuring, Simon, Podobnik, Marjetka, Anderluh, Gregor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296754/
https://www.ncbi.nlm.nih.gov/pubmed/28176876
http://dx.doi.org/10.1038/srep42231

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