Cargando…

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

The mitochondrial GTPase mitofusin-2 (MFN2) has previously been reported to play a role in regulating cell proliferation, apoptosis and differentiation in a number of cell types. Here, we report that breast cancer patients with low MFN2 expression are associated with poor prognosis as compared to pa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ke, Chen, Guo, Li, Xiaobo, Wu, Xiaoqin, Chang, Zhijie, Xu, Jianhua, Zhu, Yu, Yin, Peihao, Liang, Xin, Dong, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296837/ https://www.ncbi.nlm.nih.gov/pubmed/28176801 http://dx.doi.org/10.1038/srep41718

Ejemplares similares

High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis
por: Gayatri, Meher Bolisetti, et al.
Publicado: (2022)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling
por: Salazar, María, et al.
Publicado: (2015)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Combination of mTOR and EGFR Kinase Inhibitors Blocks mTORC1 and mTORC2 Kinase Activity and Suppresses the Progression of Colorectal Carcinoma
por: Wang, Quan, et al.
Publicado: (2013)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

RES-529: a PI3K/AKT/mTOR pathway inhibitor that dissociates the mTORC1 and mTORC2 complexes
por: Weinberg, Mark A.
Publicado: (2016)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

Regulation of mTORC2 Signaling
por: Fu, Wenxiang, et al.
Publicado: (2020)

mTORC2 Steals the Spotlight
por: Jansen, Laura A.
Publicado: (2020)

Pyruvate Kinase M2 Activates mTORC1 by Phosphorylating AKT1S1
por: He, Chang-Liang, et al.
Publicado: (2016)

mTORC1 is necessary but mTORC2 and GSK3β are inhibitory for AKT3-induced axon regeneration in the central nervous system
por: Miao, Linqing, et al.
Publicado: (2016)

GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells
por: Joha, S, et al.
Publicado: (2012)

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2
por: Humphrey, Sean J., et al.
Publicado: (2013)

TGFβ-Induced Deptor Suppression Recruits mTORC1 and Not mTORC2 to Enhance Collagen I (α2) Gene Expression
por: Das, Falguni, et al.
Publicado: (2014)

Disruption of the Keap1-mTORC2 axis by cancer-derived Keap1/mLST8 mutations leads to oncogenic mTORC2-AKT activation
por: Chen, Yingji, et al.
Publicado: (2023)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
por: Wang, Fangjie, et al.
Publicado: (2018)

AMPK suppresses Th2 cell responses by repressing mTORC2
por: Pandit, Mahesh, et al.
Publicado: (2022)

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt
por: Meng, Haitao, et al.
Publicado: (2013)

Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis
por: Liao, Minqi, et al.
Publicado: (2021)

Livers with Constitutive mTORC1 Activity Resist Steatosis Independent of Feedback Suppression of Akt
por: Kenerson, Heidi L., et al.
Publicado: (2015)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

TET2 is required to suppress mTORC1 signaling through urea cycle with therapeutic potential
por: He, Jing, et al.
Publicado: (2023)

TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation
por: Kim, Hyun-Kyoung, et al.
Publicado: (2020)

Towards specific inhibition of mTORC2
por: Murray, Elizabeth R., et al.
Publicado: (2017)

Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
por: Zhang, Hui H., et al.
Publicado: (2009)

mTORC2/Akt activation in adipocytes is required for adipose tissue inflammation in tuberculosis
por: Martinez, Nuria, et al.
Publicado: (2019)

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signaling to suppress tumorigenesis
por: Liu, Pengda, et al.
Publicado: (2013)

Targeted suppression of mTORC2 reduces seizures across models of epilepsy
por: Okoh, James, et al.
Publicado: (2023)

Halofuginone inhibits colorectal cancer growth through suppression of Akt/mTORC1 signaling and glucose metabolism
por: Chen, Guo-Qing, et al.
Publicado: (2015)

Association of crumbs homolog-2 with mTORC1 in developing podocyte
por: Hamano, Sho, et al.
Publicado: (2018)

Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication
por: Kuss-Duerkop, Sharon K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_0hlml9os07ai1h7aeps4qpuoah