Respiratory impedance is correlated with morphological changes in the lungs on three-dimensional CT in patients with COPD

The forced oscillation technique provides information concerning respiratory impedance, which comprises resistance and reactance of the respiratory system. However, its relationship with morphological changes of the lungs in chronic obstructive pulmonary disease (COPD) remains unclear. Respiratory impedance and spirometric data were evaluated in 98 patients with COPD and 49 reference subjects. Wall thickness (WT) and airway intraluminal area (Ai) of third- to sixth-generation bronchi, and percentage low-attenuation area with less than −950 HU (%LAA) of lungs were measured using three-dimensional computed tomography. COPD patients had higher respiratory impedance, decreased Ai, and increased %LAA compared with reference subjects. Indices of respiratory resistance and reactance and forced expiratory volume in 1 second (FEV(1)) were correlated with Ai, and the association between percent predicted FEV(1) and Ai was predominant in distal bronchi. The difference in respiratory resistance between 5 Hz and 20 Hz (R5–R20) and FEV(1)/forced vital capacity ratio (FEV(1)/FVC) were correlated with WT. The %LAA was correlated with the FEV(1)/FVC ratio and respiratory reactance. Airway function measurements with the forced oscillation technique provide complementary information to spirometry in COPD.