Marine Streptomyces sp. derived antimycin analogues suppress HeLa cells via depletion HPV E6/E7 mediated by ROS-dependent ubiquitin–proteasome system

Four new antimycin alkaloids (1–4) and six related known analogs (5–10) were isolated from the culture of a marine derived Streptomyces sp. THS-55, and their structures were elucidated by extensive spectroscopic analysis. All of the compounds exhibited potent cytotoxicity in vitro against HPV-transf...

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Detalles Bibliográficos
Autores principales: Zhang, Weiyi, Che, Qian, Tan, Hongsheng, Qi, Xin, Li, Jing, Li, Dehai, Gu, Qianqun, Zhu, Tianjiao, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296914/
https://www.ncbi.nlm.nih.gov/pubmed/28176847
http://dx.doi.org/10.1038/srep42180

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