Cargando…

Marrow adipocytes inhibit the differentiation of mesenchymal stem cells into osteoblasts via suppressing BMP-signaling

BACKGROUND: Reduced bone formation is associated with increased bone marrow fat in many bone-loss related diseases including aging, post-menopause, and anorexia nervosa. Several lines of evidence suggested the regulation of osteogenesis and adipogenesis of the bone marrow-derived mesenchymal (skelet...

Descripción completa

Detalles Bibliográficos
Autor principal:	Abdallah, Basem M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296965/ https://www.ncbi.nlm.nih.gov/pubmed/28173811 http://dx.doi.org/10.1186/s12929-017-0321-4

Ejemplares similares

5′-hydroxy Auraptene stimulates osteoblast differentiation of bone marrow-derived mesenchymal stem cells via a BMP-dependent mechanism
por: Abdallah, Basem M., et al.
Publicado: (2019)

Carnosol induces the osteogenic differentiation of bone marrow-derived mesenchymal stem cells via activating BMP-signaling pathway
por: Abdallah, Basem M.
Publicado: (2021)

The BMP signaling pathway enhances the osteoblastic differentiation of bone marrow mesenchymal stem cells in rats with osteoporosis
por: Zhao, Bin, et al.
Publicado: (2019)

Differentiation of Bone Marrow Mesenchymal Stem Cells in Osteoblasts and Adipocytes and its Role in Treatment of Osteoporosis
por: Wang, Cheng, et al.
Publicado: (2016)

Curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation
por: Gu, Qiaoli, et al.
Publicado: (2012)

BMP9-induced osteoblastic differentiation requires functional Notch signaling in mesenchymal stem cells
por: Cui, Jing, et al.
Publicado: (2018)

Bioinformatics analysis on the differentiation of bone mesenchymal stem cells into osteoblasts and adipocytes
por: Xu, Xiaoyuan, et al.
Publicado: (2017)

Butein Promotes Lineage Commitment of Bone Marrow-Derived Stem Cells into Osteoblasts via Modulating ERK1/2 Signaling Pathways
por: Abdallah, Basem M., et al.
Publicado: (2020)

Gene amplification in mesenchymal stem cells and during differentiation towards adipocytes or osteoblasts
por: Altmayer, Nora Corinna, et al.
Publicado: (2017)

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?
por: Chen, Q, et al.
Publicado: (2016)

miR-23a/b regulates the balance between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells
por: Guo, Qi, et al.
Publicado: (2016)

Small molecule T63 suppresses osteoporosis by modulating osteoblast differentiation via BMP and WNT signaling pathways
por: Zhao, Xiao-li, et al.
Publicado: (2017)

Effect of Mesenchymal Stem Cells Overexpressing BMP-9 Primed with Hypoxia on BMP Targets, Osteoblast Differentiation and Bone Repair
por: Paz, Jessica Emanuella Rocha Moura, et al.
Publicado: (2023)

Characterization of human mesenchymal stem cell secretome at early steps of adipocyte and osteoblast differentiation
por: Chiellini, Chiara, et al.
Publicado: (2008)

Alterations in chromatin accessibility during osteoblast and adipocyte differentiation in human mesenchymal stem cells
por: Liu, Jianyun, et al.
Publicado: (2022)

Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes
por: Kao, Richard, et al.
Publicado: (2012)

Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages
por: Chen, D., et al.
Publicado: (1998)

MicroRNA-155 inhibits the osteogenic differentiation of mesenchymal stem cells induced by BMP9 via downregulation of BMP signaling pathway
por: Liu, Hongxia, et al.
Publicado: (2018)

Effects of inhibiting PDK-1 expression in bone marrow mesenchymal stem cells on osteoblast differentiation in vitro
por: Bai, Yiguang, et al.
Publicado: (2021)

Ligustrum japonicum Thunb. Fruits Exert Antiosteoporotic Properties in Bone Marrow-Derived Mesenchymal Stromal Cells via Regulation of Adipocyte and Osteoblast Differentiation
por: Oh, Jung Hwan, et al.
Publicado: (2021)

BST2 Mediates Osteoblast Differentiation via the BMP2 Signaling Pathway in Human Alveolar-Derived Bone Marrow Stromal Cells
por: Yoo, Su-Hyang, et al.
Publicado: (2016)

Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2–Smad 1/5/8 signaling in human mesenchymal stem cells
por: Kim, Beom Su, et al.
Publicado: (2015)

Characterization of adipocyte differentiation from human mesenchymal stem cells in bone marrow
por: Qian, Shu-Wen, et al.
Publicado: (2010)

miR-765 inhibits the osteogenic differentiation of human bone marrow mesenchymal stem cells by targeting BMP6 via regulating the BMP6/Smad1/5/9 signaling pathway
por: Wang, Tao, et al.
Publicado: (2020)

KR-12-a6 promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells via BMP/SMAD signaling
por: Fu, Lanqing, et al.
Publicado: (2020)

Deletion of BMP receptor type IB decreased bone mass in association with compromised osteoblastic differentiation of bone marrow mesenchymal progenitors
por: Shi, Ce, et al.
Publicado: (2016)

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation
por: Chen, Guiqian, et al.
Publicado: (2012)

BMP14 induces tenogenic differentiation of bone marrow mesenchymal stem cells in vitro
por: Wang, Dan, et al.
Publicado: (2018)

A biological study establishing the endotoxin limit for osteoblast and adipocyte differentiation of human mesenchymal stem cells
por: Nomura, Yusuke, et al.
Publicado: (2018)

Scara3 regulates bone marrow mesenchymal stem cell fate switch between osteoblasts and adipocytes by promoting Foxo1
por: Chen, Peng, et al.
Publicado: (2021)

Insights into the osteoblast precursor differentiation towards mature osteoblasts induced by continuous BMP-2 signaling
por: Zouani, Omar F., et al.
Publicado: (2013)

All-Trans Retinoic Acid Inhibits Bone Marrow Mesenchymal Stem Cell Commitment to Adipocytes via Upregulating FRA1 Signaling
por: Xie, Linjun, et al.
Publicado: (2020)

Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation
por: Onishi, M, et al.
Publicado: (2013)

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation
por: Edwards, Daniel F., et al.
Publicado: (2021)

miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation
por: Kureel, J, et al.
Publicado: (2014)

Wnt/β-Catenin Pathway Is Involved in Cadmium-Induced Inhibition of Osteoblast Differentiation of Bone Marrow Mesenchymal Stem Cells
por: Wu, Lu, et al.
Publicado: (2019)

β-Catenin Directly Sequesters Adipocytic and Insulin Sensitizing Activities but Not Osteoblastic Activity of PPARγ2 in Marrow Mesenchymal Stem Cells
por: Rahman, Sima, et al.
Publicado: (2012)

TM9SF4 is a novel regulator in lineage commitment of bone marrow mesenchymal stem cells to either osteoblasts or adipocytes
por: Yu, Libo, et al.
Publicado: (2021)

Efficient Differentiation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Mesenchymal Progenitors Into Adipocytes and Osteoblasts
por: Diaz-Hernandez, Martha Elena, et al.
Publicado: (2023)

PDZRN3 Negatively Regulates BMP-2–induced Osteoblast Differentiation through Inhibition of Wnt Signaling
por: Honda, Takeshi, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_4cv14m28kimhkfkts65486576g