Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production

BACKGROUND: The insulin-like growth factor 1 (IGF1) signaling axis plays a major role in tumorigenesis. In a previous experiment, we chronically treated mice with several agonists of the IGF1 receptor (IGF1R). We found that chronic treatment with insulin analogues with high affinity towards the IGF1...

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Detalles Bibliográficos
Autores principales: ter Braak, Bas, Siezen, Christine L., Lee, Joo S., Rao, Pooja, Voorhoeve, Charlotte, Ruppin, Eytan, van der Laan, Jan Willem, van de Water, Bob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297135/
https://www.ncbi.nlm.nih.gov/pubmed/28173837
http://dx.doi.org/10.1186/s13058-017-0802-0

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