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Metastatic biomarkers in synovial sarcoma

Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adj...

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Autores principales: de Necochea-Campion, Rosalia, Zuckerman, Lee M., Mirshahidi, Hamid R., Khosrowpour, Shahrzad, Chen, Chien-Shing, Mirshahidi, Saied
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297148/
https://www.ncbi.nlm.nih.gov/pubmed/28191313
http://dx.doi.org/10.1186/s40364-017-0083-x
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author de Necochea-Campion, Rosalia
Zuckerman, Lee M.
Mirshahidi, Hamid R.
Khosrowpour, Shahrzad
Chen, Chien-Shing
Mirshahidi, Saied
author_facet de Necochea-Campion, Rosalia
Zuckerman, Lee M.
Mirshahidi, Hamid R.
Khosrowpour, Shahrzad
Chen, Chien-Shing
Mirshahidi, Saied
author_sort de Necochea-Campion, Rosalia
collection PubMed
description Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of the fusion is unknown. Multiple biomarkers have been found to be associated with SS and are currently under investigation regarding their pathways and mechanisms of action. Further research is needed in order to develop better diagnostic screening tools and understanding of tumor behavior. Development of targeted therapies that reduce metastatic events in SS, would dramatically improve patient prognosis.
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spelling pubmed-52971482017-02-10 Metastatic biomarkers in synovial sarcoma de Necochea-Campion, Rosalia Zuckerman, Lee M. Mirshahidi, Hamid R. Khosrowpour, Shahrzad Chen, Chien-Shing Mirshahidi, Saied Biomark Res Review Synovial sarcoma (SS) is an aggressive soft tissue sarcoma (STS) that typically occurs in the extremities near a joint. Metastatic disease is common and usually occurs in the lungs and lymph nodes. Surgical management is the mainstay of treatment with chemotherapy and radiation typically used as adjuvant treatment. Although chemotherapy has a positive impact on survival, the prognosis is poor if metastatic disease occurs. The biology of sarcoma invasion and metastasis remain poorly understood. Chromosomal translocation with fusion of the SYT and SSX genes has been described and is currently used as a diagnostic marker, although the full impact of the fusion is unknown. Multiple biomarkers have been found to be associated with SS and are currently under investigation regarding their pathways and mechanisms of action. Further research is needed in order to develop better diagnostic screening tools and understanding of tumor behavior. Development of targeted therapies that reduce metastatic events in SS, would dramatically improve patient prognosis. BioMed Central 2017-02-07 /pmc/articles/PMC5297148/ /pubmed/28191313 http://dx.doi.org/10.1186/s40364-017-0083-x Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
de Necochea-Campion, Rosalia
Zuckerman, Lee M.
Mirshahidi, Hamid R.
Khosrowpour, Shahrzad
Chen, Chien-Shing
Mirshahidi, Saied
Metastatic biomarkers in synovial sarcoma
title Metastatic biomarkers in synovial sarcoma
title_full Metastatic biomarkers in synovial sarcoma
title_fullStr Metastatic biomarkers in synovial sarcoma
title_full_unstemmed Metastatic biomarkers in synovial sarcoma
title_short Metastatic biomarkers in synovial sarcoma
title_sort metastatic biomarkers in synovial sarcoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297148/
https://www.ncbi.nlm.nih.gov/pubmed/28191313
http://dx.doi.org/10.1186/s40364-017-0083-x
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