Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells

Bispecific IgG production in single host cells has been a much sought-after goal to support the clinical development of these complex molecules. Current routes to single cell production of bispecific IgG include engineering heavy chains for heterodimerization and redesign of Fab arms for selective p...

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Detalles Bibliográficos
Autores principales: Dillon, Michael, Yin, Yiyuan, Zhou, Jianhui, McCarty, Luke, Ellerman, Diego, Slaga, Dionysos, Junttila, Teemu T., Han, Guanghui, Sandoval, Wendy, Ovacik, Meric A., Lin, Kedan, Hu, Zhilan, Shen, Amy, Corn, Jacob E., Spiess, Christoph, Carter, Paul J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297516/
https://www.ncbi.nlm.nih.gov/pubmed/27929752
http://dx.doi.org/10.1080/19420862.2016.1267089

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