Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells

Colorectal cancer is the third most common cancer worldwide. Aberrant overexpression of antiapoptotic BCL-2 (B-cell lymphoma 2) family proteins is closely linked to tumorigenesis and poor prognosis in colorectal cancer. Obatoclax is an inhibitor targeting all antiapoptotic BCL-2 proteins. A previous...

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Detalles Bibliográficos
Autores principales: Or, Chi-Hung R., Chang, Yachu, Lin, Wei-Cheng, Lee, Wee-Chyan, Su, Hong-Lin, Cheung, Muk-Wing, Huang, Chang-Po, Ho, Cheesang, Chang, Chia-Che
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297679/
https://www.ncbi.nlm.nih.gov/pubmed/28035994
http://dx.doi.org/10.3390/ijms18010044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297679/
https://www.ncbi.nlm.nih.gov/pubmed/28035994
http://dx.doi.org/10.3390/ijms18010044

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