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Obatoclax, a Pan-BCL-2 Inhibitor, Targets Cyclin D1 for Degradation to Induce Antiproliferation in Human Colorectal Carcinoma Cells

Colorectal cancer is the third most common cancer worldwide. Aberrant overexpression of antiapoptotic BCL-2 (B-cell lymphoma 2) family proteins is closely linked to tumorigenesis and poor prognosis in colorectal cancer. Obatoclax is an inhibitor targeting all antiapoptotic BCL-2 proteins. A previous...

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Detalles Bibliográficos
Autores principales:	Or, Chi-Hung R., Chang, Yachu, Lin, Wei-Cheng, Lee, Wee-Chyan, Su, Hong-Lin, Cheung, Muk-Wing, Huang, Chang-Po, Ho, Cheesang, Chang, Chia-Che
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297679/ https://www.ncbi.nlm.nih.gov/pubmed/28035994 http://dx.doi.org/10.3390/ijms18010044

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