Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives

The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly...

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Detalles Bibliográficos
Autores principales: Giovannini, Catia, Bolondi, Luigi, Gramantieri, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297691/
https://www.ncbi.nlm.nih.gov/pubmed/28036048
http://dx.doi.org/10.3390/ijms18010056
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author Giovannini, Catia
Bolondi, Luigi
Gramantieri, Laura
author_facet Giovannini, Catia
Bolondi, Luigi
Gramantieri, Laura
author_sort Giovannini, Catia
collection PubMed
description The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role.
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spelling pubmed-52976912017-02-10 Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives Giovannini, Catia Bolondi, Luigi Gramantieri, Laura Int J Mol Sci Review The Notch signaling pathway is a very conserved system that controls embryonic cell fate decisions and the maintenance of adult stem cells through cell to cell communication. Accumulating evidence support the relevance of Notch signaling in different human diseases and it is one of the most commonly activated signaling pathways in cancer. This review focuses mainly on the role of Notch3 signaling in hepatocellular carcinoma and its potential therapeutic applications against this malignancy. In this regard, the crosstalk between Notch and p53 may play an important role. MDPI 2016-12-28 /pmc/articles/PMC5297691/ /pubmed/28036048 http://dx.doi.org/10.3390/ijms18010056 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Giovannini, Catia
Bolondi, Luigi
Gramantieri, Laura
Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title_full Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title_fullStr Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title_full_unstemmed Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title_short Targeting Notch3 in Hepatocellular Carcinoma: Molecular Mechanisms and Therapeutic Perspectives
title_sort targeting notch3 in hepatocellular carcinoma: molecular mechanisms and therapeutic perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297691/
https://www.ncbi.nlm.nih.gov/pubmed/28036048
http://dx.doi.org/10.3390/ijms18010056
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