R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4

R-flurbiprofen is the non-COX-inhibiting enantiomer of flurbiprofen and is not converted to S-flurbiprofen in human cells. Nevertheless, it reduces extracellular prostaglandin E(2) (PGE(2)) in cancer or immune cell cultures and human extracellular fluid. Here, we show that R-flurbiprofen acts throug...

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Detalles Bibliográficos
Autores principales: Wobst, Ivonne, Ebert, Lisa, Birod, Kerstin, Wegner, Marthe-Susanna, Hoffmann, Marika, Thomas, Dominique, Angioni, Carlo, Parnham, Michael J., Steinhilber, Dieter, Tegeder, Irmgard, Geisslinger, Gerd, Grösch, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297703/
https://www.ncbi.nlm.nih.gov/pubmed/28042832
http://dx.doi.org/10.3390/ijms18010068

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